Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 446833..447486 Replicon chromosome
Accession NZ_CP096812
Organism Acinetobacter baumannii strain 51248

Toxin (Protein)


Gene name cptA Uniprot ID A0A5N0FZY3
Locus tag M2A29_RS02170 Protein ID WP_000607074.1
Coordinates 447097..447486 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag M2A29_RS02165 Protein ID WP_001288210.1
Coordinates 446833..447090 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2A29_RS02145 (M2A29_02145) 442349..443356 + 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -
M2A29_RS02150 (M2A29_02150) 443375..443752 + 378 WP_001216380.1 50S ribosomal protein L17 -
M2A29_RS02155 (M2A29_02155) 443934..445424 + 1491 WP_032046399.1 NAD(P)/FAD-dependent oxidoreductase -
M2A29_RS02160 (M2A29_02160) 445473..446645 - 1173 WP_001190546.1 acyl-CoA dehydrogenase family protein -
M2A29_RS02165 (M2A29_02165) 446833..447090 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
M2A29_RS02170 (M2A29_02170) 447097..447486 + 390 WP_000607074.1 membrane protein Toxin
M2A29_RS02175 (M2A29_02175) 448256..449341 + 1086 WP_000049106.1 hypothetical protein -
M2A29_RS02180 (M2A29_02180) 449419..449985 + 567 WP_000651536.1 rhombosortase -
M2A29_RS02185 (M2A29_02185) 450173..452368 + 2196 WP_001158905.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15621.89 Da        Isoelectric Point: 10.3890

>T243381 WP_000607074.1 NZ_CP096812:447097-447486 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKVIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T243381 NZ_OX030705:4537-4788 [Escherichia coli]
ATGAGAAAAAATAAAGGTGATGTGACTTATTTTCTTGAAAAAGAAGGTGACAATTACAGGCTTACAAAAAGGATAAAAGC
CAGAACAAATGTTAAAATCGGGAACAAAACTACGAAAATTACATTGTATGATGCTGTACTGAATGAGAATGAATTACAAC
ATATTGATTTTACGTGTGCCGGATTAAGGGAAGACGATGAGACGCCAGTTAAGAATTTAATTAAGGAGTTTATGTTAAAT
GAAACCCGATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT243381 WP_001288210.1 NZ_CP096812:446833-447090 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT243381 NZ_OX030705:4775-5002 [Escherichia coli]
ATGAAACCCGATAATACACCTGAAAATGTAAAAAAATTACGTTTAAAAGCAGGATTAACACAAAAGGAATGCAGTCATAT
TTATGGTGTTGGGCTAAGAACCTGGCAGAAAAAAGAGGAAGTTAATACTCAAAACAGTCAAAGTCTGTCACTGGTTGAGT
TTGAGTTTCTTTTGTTACTTGCAGGAGAACATCCTGAATACGTGCTCTGCAAAAGGGAGTCAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5N0FZY3

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References