Detailed information of TA system TA024338

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 5581664..5582496
• Replicon: chromosome
• Accession: NC_013361
• Organism: Escherichia coli O26:H11 str. 11368

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: S1PD64
• Locus tag: ECO26_RS28990
• Protein ID: WP_000854753.1
• Coordinates: 5582122..5582496 (+)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: V0ULY5
• Locus tag: ECO26_RS28985
• Protein ID: WP_001315620.1
• Coordinates: 5581664..5582032 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ECO26_RS28950	5578500..5578955	+	456	WP_000581504.1	hypothetical protein	-
ECO26_RS28955	5579034..5579267	+	234	WP_001119729.1	DUF905 family protein	-
ECO26_RS28960	5579367..5580185	+	819	WP_001234622.1	DUF945 domain-containing protein	-
ECO26_RS28965	5580240..5580725	+	486	WP_000849588.1	antirestriction protein	-
ECO26_RS28970	5580741..5581217	+	477	WP_001186774.1	RadC family protein	-
ECO26_RS28975	5581280..5581501	+	222	WP_000692345.1	DUF987 domain-containing protein	-
ECO26_RS28985	5581664..5582032	+	369	WP_001315620.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
ECO26_RS28990	5582122..5582496	+	375	WP_000854753.1	TA system toxin CbtA family protein	Toxin
ECO26_RS28995	5582493..5582981	+	489	WP_000777547.1	hypothetical protein	-
ECO26_RS29000	5582993..5583190	+	198	WP_000839281.1	DUF957 domain-containing protein	-
ECO26_RS34925	5583275..5583427	+	153	WP_001280445.1	hypothetical protein	-
ECO26_RS29015	5584472..5585122	+	651	WP_001037966.1	HNH endonuclease	-
ECO26_RS29020	5585130..5586110	-	981	WP_000991415.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
ECO26_RS29025	5586175..5587281	-	1107	Protein_5511	N-acetylneuraminate epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 14005.00 Da
• Isoelectric Point: 8.2905

>T24338 WP_000854753.1 NC_013361:5582122-5582496 [Escherichia coli O26:H11 str. 11368]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Nucleotide

• Length: 375 bp

>T24338 NC_013361:5582122-5582496 [Escherichia coli O26:H11 str. 11368]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13474.20 Da
• Isoelectric Point: 6.2050

>AT24338 WP_001315620.1 NC_013361:5581664-5582032 [Escherichia coli O26:H11 str. 11368]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT24338 NC_013361:5581664-5582032 [Escherichia coli O26:H11 str. 11368]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Structures

Toxin

• AlphaFold DB: A0A7U9LVU0

Antitoxin

• AlphaFold DB: V0ULY5