243372

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 5148212..5148855 Replicon chromosome
Accession NZ_CP096810
Organism Klebsiella pneumoniae strain Bio19

Toxin (Protein)


Gene name vagD Uniprot ID A0A5Q9LNG2
Locus tag MOV22_RS24900 Protein ID WP_048983057.1
Coordinates 5148212..5148628 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID R4IT22
Locus tag MOV22_RS24905 Protein ID WP_016338373.1
Coordinates 5148625..5148855 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOV22_RS24880 (5143260) 5143260..5145368 - 2109 WP_016338368.1 peptidase domain-containing ABC transporter -
MOV22_RS24885 (5145358) 5145358..5146635 - 1278 WP_016338369.1 HlyD family secretion protein -
MOV22_RS24890 (5147294) 5147294..5147830 + 537 WP_223825639.1 hypothetical protein -
MOV22_RS24895 (5147848) 5147848..5148171 + 324 WP_085842301.1 hypothetical protein -
MOV22_RS24900 (5148212) 5148212..5148628 - 417 WP_048983057.1 type II toxin-antitoxin system VapC family toxin Toxin
MOV22_RS24905 (5148625) 5148625..5148855 - 231 WP_016338373.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MOV22_RS24910 (5149500) 5149500..5150480 - 981 WP_000019403.1 IS5-like element IS5 family transposase -
MOV22_RS24915 (5150526) 5150526..5151194 - 669 WP_032249507.1 LuxR C-terminal-related transcriptional regulator -
MOV22_RS24920 (5151392) 5151392..5152360 - 969 WP_077265821.1 IS5 family transposase -
MOV22_RS24925 (5152690) 5152690..5152986 + 297 WP_001542733.1 helix-turn-helix transcriptional regulator -
MOV22_RS24930 (5153248) 5153248..5153436 - 189 Protein_4903 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 5143260..5157862 14602


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15022.52 Da        Isoelectric Point: 9.2957

>T243372 WP_048983057.1 NZ_CP096810:c5148628-5148212 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFARVPGLVLEDWVK

Download         Length: 417 bp

>T243372 NZ_OX030701:3658477-3658761 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGATAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAATGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8751.77 Da        Isoelectric Point: 4.3533

>AT243372 WP_016338373.1 NZ_CP096810:c5148855-5148625 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWSSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp

>AT243372 NZ_OX030701:3658241-3658474 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Q9LNG2

Antitoxin

Source ID Structure
AlphaFold DB A0A5Q9LN61

References