243366

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 2849905..2851586 Replicon chromosome
Accession NZ_CP096810
Organism Klebsiella pneumoniae strain Bio19

Toxin (Protein)


Gene name mosT Uniprot ID A0A486RE08
Locus tag MOV22_RS13805 Protein ID WP_023287018.1
Coordinates 2849905..2850822 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A0A486RD25
Locus tag MOV22_RS13810 Protein ID WP_023287017.1
Coordinates 2850828..2851586 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOV22_RS13785 (2845211) 2845211..2846731 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
MOV22_RS13790 (2846728) 2846728..2847726 + 999 WP_002885172.1 ribose ABC transporter permease -
MOV22_RS13795 (2847757) 2847757..2848698 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
MOV22_RS13800 (2848773) 2848773..2849780 + 1008 WP_023287019.1 carbohydrate kinase family protein -
MOV22_RS13805 (2849905) 2849905..2850822 - 918 WP_023287018.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
MOV22_RS13810 (2850828) 2850828..2851586 - 759 WP_023287017.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
MOV22_RS13815 (2851672) 2851672..2852400 - 729 WP_002885152.1 response regulator transcription factor -
MOV22_RS13820 (2852673) 2852673..2854820 + 2148 WP_012737173.1 formate dehydrogenase H subunit alpha, selenocysteine-containing -
MOV22_RS13825 (2855050) 2855050..2855736 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34587.04 Da        Isoelectric Point: 5.7772

>T243366 WP_023287018.1 NZ_CP096810:c2850822-2849905 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIGVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

>T243366 NZ_OX030701:c2495337-2495230 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28534.90 Da        Isoelectric Point: 10.0870

>AT243366 WP_023287017.1 NZ_CP096810:c2851586-2850828 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVVSGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp

>AT243366 NZ_OX030701:2495386-2495451 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486RE08

Antitoxin

Source ID Structure
AlphaFold DB A0A486RD25

References