Detailed information of TA system TA243364

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 2614559..2615239
• Replicon: chromosome
• Accession: NZ_CP096810
• Organism: Klebsiella pneumoniae strain Bio19

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: MOV22_RS12645
• Protein ID: WP_087775046.1
• Coordinates: 2614559..2614879 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A483NFV3
• Locus tag: MOV22_RS12650
• Protein ID: WP_004186786.1
• Coordinates: 2614916..2615239 (-)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOV22_RS12630 (2612199)	2612199..2613149	-	951	WP_004186795.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
MOV22_RS12635 (2613142)	2613142..2613537	-	396	WP_004186793.1	DUF6088 family protein	-
MOV22_RS12640 (2613612)	2613612..2614445	-	834	WP_087775048.1	DUF4942 domain-containing protein	-
MOV22_RS12645 (2614559)	2614559..2614879	-	321	WP_087775046.1	TA system toxin CbtA family protein	Toxin
MOV22_RS12650 (2614916)	2614916..2615239	-	324	WP_004186786.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
MOV22_RS12655 (2615252)	2615252..2615722	-	471	WP_004186785.1	DNA repair protein RadC	-
MOV22_RS12660 (2615747)	2615747..2616601	-	855	WP_087775044.1	DUF932 domain-containing protein	-
MOV22_RS12665 (2616711)	2616711..2617172	-	462	WP_019704405.1	IrmA family protein	-
MOV22_RS12670 (2617290)	2617290..2617919	-	630	WP_004186778.1	hypothetical protein	-
MOV22_RS12675 (2617925)	2617925..2618626	-	702	WP_114507577.1	WYL domain-containing protein	-
MOV22_RS12680 (2618839)	2618839..2619714	-	876	WP_114507578.1	GTPase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (11-105)

Antitoxin

• Antitoxin CbeA (7-106)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 11995.64 Da
• Isoelectric Point: 6.3221

>T243364 WP_087775046.1 NZ_CP096810:c2614879-2614559 [Klebsiella pneumoniae]
MHISTVPAKVPVSSRLSPVQVWQQLLTYLLGHHYGLTLNDTPFHDDAAIEEHIDAGITLADAVNFLVERYELVRIDRKGF
SWQEQNPFLTATDILRARRATGLINT

Nucleotide

• Length: 321 bp

>T243364 NZ_OX030701:c2392356-2391829 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCATT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTCTGCGAGCGTATATCCTGTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTAACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTTGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCATTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCGACCAAATCTATAGAGCTACTTTTTACACCAGACGATTAA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 12005.80 Da
• Isoelectric Point: 6.4664

>AT243364 WP_004186786.1 NZ_CP096810:c2615239-2614916 [Klebsiella pneumoniae]
MSITPPHEWGLQSDITPRFGARLVQEGNRLYYLADRAGLTGSFSPMHLQKIDLAFPLFVEQLEDMLHAGELNPHQQCQVK
IQLASLTCIADTRGSCGYVYISIYPKP

Nucleotide

• Length: 324 bp

>AT243364 NZ_OX030701:c2392629-2392363 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATTGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCACTGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Structures

Antitoxin

• AlphaFold DB: A0A483NFV3