243361

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2328036..2328655 Replicon chromosome
Accession NZ_CP096810
Organism Klebsiella pneumoniae strain Bio19

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag MOV22_RS11345 Protein ID WP_002892050.1
Coordinates 2328036..2328254 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag MOV22_RS11350 Protein ID WP_002892066.1
Coordinates 2328281..2328655 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOV22_RS11310 (2324083) 2324083..2324346 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
MOV22_RS11315 (2324346) 2324346..2324486 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
MOV22_RS11320 (2324483) 2324483..2325181 - 699 WP_002892021.1 GNAT family protein -
MOV22_RS11325 (2325282) 2325282..2326733 + 1452 WP_087775295.1 PLP-dependent aminotransferase family protein -
MOV22_RS11330 (2326708) 2326708..2327178 - 471 WP_040187972.1 YlaC family protein -
MOV22_RS11335 (2327199) 2327199..2327339 + 141 WP_032410934.1 hypothetical protein -
MOV22_RS11340 (2327311) 2327311..2327877 - 567 WP_002892030.1 maltose O-acetyltransferase -
MOV22_RS11345 (2328036) 2328036..2328254 - 219 WP_002892050.1 HHA domain-containing protein Toxin
MOV22_RS11350 (2328281) 2328281..2328655 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
MOV22_RS11355 (2329141) 2329141..2332287 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
MOV22_RS11360 (2332310) 2332310..2333503 - 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T243361 WP_002892050.1 NZ_CP096810:c2328254-2328036 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T243361 NZ_OX030701:1859046-1859423 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCAGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT243361 WP_002892066.1 NZ_CP096810:c2328655-2328281 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT243361 NZ_OX030701:1858589-1858957 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCTCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCTGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGTACCATCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACCGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References