Detailed information of TA system
Overview
TA module
| Type | V | Classification (family/domain) | ghoTS/ghoT-GhoS |
| Location | 5318881..5319336 | Replicon | chromosome |
| Accession | NC_013361 | ||
| Organism | Escherichia coli O26:H11 str. 11368 | ||
Toxin (Protein)
| Gene name | ghoT | Uniprot ID | - |
| Locus tag | ECO26_RS27630 | Protein ID | WP_042357764.1 |
| Coordinates | 5319205..5319336 (+) | Length | 44 a.a. |
Antitoxin (Protein)
| Gene name | ghoS | Uniprot ID | L4JK92 |
| Locus tag | ECO26_RS27625 | Protein ID | WP_000398619.1 |
| Coordinates | 5318881..5319177 (+) | Length | 99 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ECO26_RS27600 | 5315612..5316331 | - | 720 | WP_000611288.1 | two-component system response regulator DcuR | - |
| ECO26_RS27605 | 5316328..5317959 | - | 1632 | WP_001216487.1 | sensor histidine kinase | - |
| ECO26_RS27610 | 5318140..5318370 | + | 231 | WP_000371700.1 | (4Fe-4S)-binding protein | - |
| ECO26_RS27615 | 5318382..5318654 | + | 273 | WP_000405647.1 | N-acetyltransferase | - |
| ECO26_RS27625 | 5318881..5319177 | + | 297 | WP_000398619.1 | type V toxin-antitoxin system endoribonuclease antitoxin GhoS | Antitoxin |
| ECO26_RS27630 | 5319205..5319336 | + | 132 | WP_042357764.1 | GhoT/OrtT family toxin | Toxin |
| ECO26_RS27635 | 5319497..5321014 | - | 1518 | WP_001295074.1 | lysine--tRNA ligase | - |
| ECO26_RS27640 | 5321251..5322708 | - | 1458 | WP_000856834.1 | dipeptide/tripeptide permease DtpC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 44 a.a. Molecular weight: 4952.06 Da Isoelectric Point: 10.2288
>T24336 WP_042357764.1 NC_013361:5319205-5319336 [Escherichia coli O26:H11 str. 11368]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGIT
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGIT
Download Length: 132 bp
>T24336 NC_013361:5319205-5319336 [Escherichia coli O26:H11 str. 11368]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTAG
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTAG
Antitoxin
Download Length: 99 a.a. Molecular weight: 11467.97 Da Isoelectric Point: 4.1705
>AT24336 WP_000398619.1 NC_013361:5318881-5319177 [Escherichia coli O26:H11 str. 11368]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK
Download Length: 297 bp
>AT24336 NC_013361:5318881-5319177 [Escherichia coli O26:H11 str. 11368]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|