Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1829733..1830390 Replicon chromosome
Accession NZ_CP096810
Organism Klebsiella pneumoniae strain Bio19

Toxin (Protein)


Gene name cptA Uniprot ID A0A483MVT4
Locus tag MOV22_RS08810 Protein ID WP_065889201.1
Coordinates 1829733..1830143 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag MOV22_RS08815 Protein ID WP_002916312.1
Coordinates 1830124..1830390 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOV22_RS08790 (1825733) 1825733..1827466 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
MOV22_RS08795 (1827472) 1827472..1828185 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MOV22_RS08800 (1828208) 1828208..1829104 - 897 WP_087774387.1 site-specific tyrosine recombinase XerD -
MOV22_RS08805 (1829205) 1829205..1829726 + 522 WP_002916308.1 flavodoxin FldB -
MOV22_RS08810 (1829733) 1829733..1830143 - 411 WP_065889201.1 protein YgfX Toxin
MOV22_RS08815 (1830124) 1830124..1830390 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
MOV22_RS08820 (1830636) 1830636..1831619 + 984 WP_023286864.1 tRNA-modifying protein YgfZ -
MOV22_RS08825 (1831770) 1831770..1832429 - 660 WP_002916317.1 hemolysin III family protein -
MOV22_RS08830 (1832593) 1832593..1832904 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
MOV22_RS08835 (1832954) 1832954..1833682 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
MOV22_RS08840 (1833801) 1833801..1835234 + 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16062.85 Da        Isoelectric Point: 11.4778

>T243359 WP_065889201.1 NZ_CP096810:c1830143-1829733 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDNRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T243359 NZ_OX030701:c790472-790221 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGACAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT243359 WP_002916312.1 NZ_CP096810:c1830390-1830124 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT243359 NZ_OX030701:c790224-789970 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAGCAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAACTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCTTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483MVT4

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References