Detailed information of TA system TA243350

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1603855..1604523
• Replicon: chromosome
• Accession: NZ_CP096809
• Organism: Streptococcus pneumoniae strain SP007

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: C1C927
• Locus tag: MZK36_RS08070
• Protein ID: WP_001132282.1
• Coordinates: 1604344..1604523 (-)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: G0IC64
• Locus tag: MZK36_RS08065
• Protein ID: WP_000961810.1
• Coordinates: 1603855..1604307 (-)
• Length: 151 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MZK36_RS08045 (MZK36_07990)	1600704..1601738	-	1035	WP_000747915.1	ATP-binding protein	-
MZK36_RS08050 (MZK36_07995)	1601872..1602006	-	135	Protein_1593	7,8-dihydro-8-oxoguanine-triphosphatase	-
MZK36_RS08055 (MZK36_08000)	1601987..1603075	-	1089	WP_000719711.1	site-2 protease family protein	-
MZK36_RS08060 (MZK36_08005)	1603094..1603564	-	471	WP_000257114.1	DUF3013 family protein	-
MZK36_RS08065 (MZK36_08010)	1603855..1604307	-	453	WP_000961810.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
MZK36_RS08070 (MZK36_08015)	1604344..1604523	-	180	WP_001132282.1	type II toxin-antitoxin system HicA family toxin	Toxin
MZK36_RS08075 (MZK36_08020)	1604660..1604839	-	180	WP_001048906.1	hypothetical protein	-
MZK36_RS08080 (MZK36_08025)	1605004..1605243	-	240	WP_000818079.1	hypothetical protein	-
MZK36_RS08085 (MZK36_08030)	1605513..1606784	+	1272	WP_001113206.1	replication-associated recombination protein A	-
MZK36_RS08095 (MZK36_08040)	1607331..1608650	-	1320	WP_000502563.1	glycoside hydrolase family 32 protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (17-114)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6713.95 Da
• Isoelectric Point: 11.0174

>T243350 WP_001132282.1 NZ_CP096809:c1604523-1604344 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERLITIPHGELNKYTERGIRKQAGL

Nucleotide

• Length: 180 bp

>T243350 NZ_OW970560:c4792208-4791675 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 151 a.a.
• Molecular weight: 16659.46 Da
• Isoelectric Point: 3.7220

>AT243350 WP_000961810.1 NZ_CP096809:c1604307-1603855 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Nucleotide

• Length: 453 bp

>AT243350 NZ_OW970560:c4792485-4792219 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Toxin

• AlphaFold DB: A0A0E7SUI3

Antitoxin

• AlphaFold DB: G0IC64