Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1603855..1604523 Replicon chromosome
Accession NZ_CP096809
Organism Streptococcus pneumoniae strain SP007

Toxin (Protein)


Gene name hicA Uniprot ID C1C927
Locus tag MZK36_RS08070 Protein ID WP_001132282.1
Coordinates 1604344..1604523 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag MZK36_RS08065 Protein ID WP_000961810.1
Coordinates 1603855..1604307 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MZK36_RS08045 (MZK36_07990) 1600704..1601738 - 1035 WP_000747915.1 ATP-binding protein -
MZK36_RS08050 (MZK36_07995) 1601872..1602006 - 135 Protein_1593 7,8-dihydro-8-oxoguanine-triphosphatase -
MZK36_RS08055 (MZK36_08000) 1601987..1603075 - 1089 WP_000719711.1 site-2 protease family protein -
MZK36_RS08060 (MZK36_08005) 1603094..1603564 - 471 WP_000257114.1 DUF3013 family protein -
MZK36_RS08065 (MZK36_08010) 1603855..1604307 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
MZK36_RS08070 (MZK36_08015) 1604344..1604523 - 180 WP_001132282.1 type II toxin-antitoxin system HicA family toxin Toxin
MZK36_RS08075 (MZK36_08020) 1604660..1604839 - 180 WP_001048906.1 hypothetical protein -
MZK36_RS08080 (MZK36_08025) 1605004..1605243 - 240 WP_000818079.1 hypothetical protein -
MZK36_RS08085 (MZK36_08030) 1605513..1606784 + 1272 WP_001113206.1 replication-associated recombination protein A -
MZK36_RS08095 (MZK36_08040) 1607331..1608650 - 1320 WP_000502563.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.95 Da        Isoelectric Point: 11.0174

>T243350 WP_001132282.1 NZ_CP096809:c1604523-1604344 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERLITIPHGELNKYTERGIRKQAGL

Download         Length: 180 bp

>T243350 NZ_OW970560:c4792208-4791675 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT243350 WP_000961810.1 NZ_CP096809:c1604307-1603855 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT243350 NZ_OW970560:c4792485-4792219 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E7SUI3

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References