Detailed information of TA system TA243349

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 925674..926172
• Replicon: chromosome
• Accession: NZ_CP096809
• Organism: Streptococcus pneumoniae strain SP007

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MZK36_RS04705
• Protein ID: WP_001812387.1
• Coordinates: 925918..926172 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B1IC20
• Locus tag: MZK36_RS04700
• Protein ID: WP_000208080.1
• Coordinates: 925674..925916 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MZK36_RS04680 (MZK36_04645)	921496..922671	+	1176	WP_000886147.1	A/G-specific adenine glycosylase	-
MZK36_RS04685 (MZK36_04650)	922726..923430	+	705	WP_000722076.1	response regulator YycF	-
MZK36_RS04690 (MZK36_04655)	923423..924772	+	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	-
MZK36_RS04695 (MZK36_04660)	924774..925583	+	810	WP_001289493.1	MBL fold metallo-hydrolase	-
MZK36_RS04700 (MZK36_04665)	925674..925916	+	243	WP_000208080.1	DUF6290 family protein	Antitoxin
MZK36_RS04705 (MZK36_04670)	925918..926172	+	255	WP_001812387.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MZK36_RS04710 (MZK36_04675)	926219..926992	+	774	WP_000731129.1	ion channel	-
MZK36_RS04715 (MZK36_04680)	927308..928654	-	1347	WP_001821303.1	IS1380-like element ISSpn5 family transposase	-
MZK36_RS04720 (MZK36_04685)	928963..929949	-	987	WP_000204727.1	L-lactate dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	927308..928654	1346

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Protein of unknown function DUF6290 (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10110.85 Da
• Isoelectric Point: 10.7632

>T243349 WP_001812387.1 NZ_CP096809:925918-926172 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQINVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Nucleotide

• Length: 255 bp

>T243349 NZ_OW970560:4163475-4163693 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9205.46 Da
• Isoelectric Point: 4.0527

>AT243349 WP_000208080.1 NZ_CP096809:925674-925916 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Nucleotide

• Length: 243 bp

>AT243349 NZ_OW970560:4163074-4163448 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A064C2J7