Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-MqsA
Location 3985219..3985918 Replicon chromosome
Accession NZ_CP096776
Organism Proteus mirabilis strain HURS-186083

Toxin (Protein)


Gene name relE Uniprot ID B4EZ96
Locus tag M1766_RS18925 Protein ID WP_004249093.1
Coordinates 3985219..3985605 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B4EZ97
Locus tag M1766_RS18930 Protein ID WP_004246828.1
Coordinates 3985598..3985918 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1766_RS18910 (M1766_18910) 3981220..3981801 - 582 WP_012368524.1 DNA-3-methyladenine glycosylase I -
M1766_RS18915 (M1766_18915) 3982052..3982957 + 906 WP_004246832.1 glycine--tRNA ligase subunit alpha -
M1766_RS18920 (M1766_18920) 3982967..3985039 + 2073 WP_248706974.1 glycine--tRNA ligase subunit beta -
M1766_RS18925 (M1766_18925) 3985219..3985605 + 387 WP_004249093.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M1766_RS18930 (M1766_18930) 3985598..3985918 + 321 WP_004246828.1 helix-turn-helix domain-containing protein Antitoxin
M1766_RS18935 (M1766_18935) 3985967..3986401 - 435 WP_004246827.1 hypothetical protein -
M1766_RS18940 (M1766_18940) 3986394..3987278 - 885 WP_012368526.1 endonuclease/exonuclease/phosphatase family protein -
M1766_RS18945 (M1766_18945) 3987495..3988781 - 1287 WP_036919265.1 DUF3748 domain-containing protein -
M1766_RS18950 (M1766_18950) 3988918..3989535 + 618 WP_004246822.1 trimeric intracellular cation channel family protein -
M1766_RS18955 (M1766_18955) 3989837..3990460 + 624 WP_004246821.1 guanylate kinase -
M1766_RS18960 (M1766_18960) 3990515..3990790 + 276 WP_004246820.1 DNA-directed RNA polymerase subunit omega -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-125)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-95)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14294.64 Da        Isoelectric Point: 10.0642

>T243347 WP_004249093.1 NZ_CP096776:3985219-3985605 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVKYD

Download         Length: 387 bp

>T243347 NZ_OW970560:2181486-2181588 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12126.21 Da        Isoelectric Point: 10.4411

>AT243347 WP_004246828.1 NZ_CP096776:3985598-3985918 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Download         Length: 321 bp

>AT243347 NZ_OW970560:c2181595-2181450 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B4EZ96

Antitoxin

Source ID Structure
AlphaFold DB B4EZ97

References