Detailed information of TA system TA243344

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 11796..12397
• Replicon: chromosome
• Accession: NZ_CP096776
• Organism: Proteus mirabilis strain HURS-186083

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: M1766_RS00050
• Protein ID: WP_017826987.1
• Coordinates: 11796..12179 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: A0A1Z1SPN9
• Locus tag: M1766_RS00055
• Protein ID: WP_004246496.1
• Coordinates: 12176..12397 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1766_RS00030 (M1766_00030)	7729..8292	+	564	WP_012368640.1	rRNA adenine N-6-methyltransferase family protein	-
M1766_RS00035 (M1766_00035)	8568..9467	+	900	WP_036919439.1	N-acetylmuramic acid 6-phosphate etherase	-
M1766_RS00040 (M1766_00040)	9824..11062	-	1239	WP_020946511.1	HipA domain-containing protein	-
M1766_RS00045 (M1766_00045)	11075..11389	-	315	WP_004246498.1	helix-turn-helix transcriptional regulator	-
M1766_RS00050 (M1766_00050)	11796..12179	-	384	WP_017826987.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
M1766_RS00055 (M1766_00055)	12176..12397	-	222	WP_004246496.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
M1766_RS00060 (M1766_00060)	12678..13541	-	864	WP_004249947.1	YicC/YloC family endoribonuclease	-
M1766_RS00065 (M1766_00065)	13668..14384	+	717	WP_004249946.1	ribonuclease PH	-
M1766_RS00070 (M1766_00070)	14466..15110	+	645	WP_036919444.1	orotate phosphoribosyltransferase	-
M1766_RS00075 (M1766_00075)	15429..16034	-	606	WP_004246491.1	nucleoid occlusion factor SlmA	-
M1766_RS00080 (M1766_00080)	16154..16612	-	459	WP_004246490.1	dUTP diphosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (3-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-52)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14481.57 Da
• Isoelectric Point: 8.5125

>T243344 WP_017826987.1 NZ_CP096776:c12179-11796 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQRFPGVAGMPDPGRAEALIYRVQNRKHYEGITDVFELAATYWVAIARGHIFNDGNKRTAFFVT
MTFLYRNGIRIRDTGNMLENLTVEAATGEKTVDQLAKHLQNLVEKTN

Nucleotide

• Length: 384 bp

>T243344 NZ_OW970560:c1147149-1146781 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGACAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8260.23 Da
• Isoelectric Point: 5.5667

>AT243344 WP_004246496.1 NZ_CP096776:c12397-12176 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR

Nucleotide

• Length: 222 bp

>AT243344 NZ_OW970560:c1147367-1147146 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A1Z1SPN9