Detailed information of TA system TA243342

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 3985233..3985932
• Replicon: chromosome
• Accession: NZ_CP096775
• Organism: Proteus mirabilis strain HURS-181823

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B4EZ96
• Locus tag: M1765_RS18945
• Protein ID: WP_004249093.1
• Coordinates: 3985233..3985619 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B4EZ97
• Locus tag: M1765_RS18950
• Protein ID: WP_004246828.1
• Coordinates: 3985612..3985932 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1765_RS18930 (M1765_18930)	3981234..3981815	-	582	WP_012368524.1	DNA-3-methyladenine glycosylase I	-
M1765_RS18935 (M1765_18935)	3982066..3982971	+	906	WP_004246832.1	glycine--tRNA ligase subunit alpha	-
M1765_RS18940 (M1765_18940)	3982981..3985053	+	2073	WP_248706974.1	glycine--tRNA ligase subunit beta	-
M1765_RS18945 (M1765_18945)	3985233..3985619	+	387	WP_004249093.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
M1765_RS18950 (M1765_18950)	3985612..3985932	+	321	WP_004246828.1	helix-turn-helix domain-containing protein	Antitoxin
M1765_RS18955 (M1765_18955)	3985981..3986415	-	435	WP_004246827.1	hypothetical protein	-
M1765_RS18960 (M1765_18960)	3986408..3987292	-	885	WP_012368526.1	endonuclease/exonuclease/phosphatase family protein	-
M1765_RS18965 (M1765_18965)	3987509..3988795	-	1287	WP_036919265.1	DUF3748 domain-containing protein	-
M1765_RS18970 (M1765_18970)	3988932..3989549	+	618	WP_004246822.1	trimeric intracellular cation channel family protein	-
M1765_RS18975 (M1765_18975)	3989851..3990474	+	624	WP_004246821.1	guanylate kinase	-
M1765_RS18980 (M1765_18980)	3990529..3990804	+	276	WP_004246820.1	DNA-directed RNA polymerase subunit omega	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-95)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14294.64 Da
• Isoelectric Point: 10.0642

>T243342 WP_004249093.1 NZ_CP096775:3985233-3985619 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVKYD

Nucleotide

• Length: 387 bp

>T243342 NZ_OW970560:928414-928824 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12126.21 Da
• Isoelectric Point: 10.4411

>AT243342 WP_004246828.1 NZ_CP096775:3985612-3985932 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Nucleotide

• Length: 321 bp

>AT243342 NZ_OW970560:928167-928433 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: B4EZ96

Antitoxin

• AlphaFold DB: B4EZ97