Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/PIN-RelB
Location 969924..970777 Replicon chromosome
Accession NZ_CP096771
Organism Bifidobacterium longum strain W13

Toxin (Protein)


Gene name relE Uniprot ID A0A0A0UEJ8
Locus tag M1764_RS03895 Protein ID WP_038426455.1
Coordinates 970286..970777 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0A1GRX0
Locus tag M1764_RS03890 Protein ID WP_041080656.1
Coordinates 969924..970286 (+) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1764_RS03885 (M1764_03885) 967080..969779 + 2700 WP_013582802.1 aconitate hydratase AcnA -
M1764_RS03890 (M1764_03890) 969924..970286 + 363 WP_041080656.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M1764_RS03895 (M1764_03895) 970286..970777 + 492 WP_038426455.1 PIN domain-containing protein Toxin
M1764_RS03900 (M1764_03900) 970839..972944 - 2106 WP_248703142.1 DUF262 domain-containing protein -
M1764_RS03905 (M1764_03905) 973034..973675 - 642 WP_007052627.1 GNAT family N-acetyltransferase -
M1764_RS03910 (M1764_03910) 973715..974440 - 726 WP_007056206.1 response regulator transcription factor -
M1764_RS03915 (M1764_03915) 974475..975707 - 1233 Protein_751 histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 856366..993905 137539


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-141)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-53)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 18273.79 Da        Isoelectric Point: 4.4719

>T243338 WP_038426455.1 NZ_CP096771:970286-970777 [Bifidobacterium longum]
MTDVSMQRILLDTNVLLDYLLHRDDHAKMAEAVMELGAKNNVTLLCASLSLKDIAYLSSSAIRSEFKPNESEVENFTRGF
LSSRVPWRCIEQVKEMCDIVAVDESTCDRAFSLQKRHRDFEDDLIIVAAQQSGANCVVTSDAELISHFPEYCKTPAEIVA
ALE

Download         Length: 492 bp

>T243338 NZ_OW970555:c49640-49224 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGTGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCGTGGGACCGGGCT
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGCACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGACACGCCATCGCGGCGGGCGCCATCCTGGTGACGAATAATACAAGAGAGTTTGCGCGGGTCCCGGGCCTGGTGCTGG
AAGACTGGGTGAATTAA

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 14002.08 Da        Isoelectric Point: 5.0733

>AT243338 WP_041080656.1 NZ_CP096771:969924-970286 [Bifidobacterium longum]
MTMVQMNVRIDAKLKNEVEEVLKGKGVSVSDVIRSLWLYIADRKEVPALETTAEEQAREEEKQRKLKLIREGAGYVHKEL
VKAGLISEDTDLMEGLTYKQFRDKMYDEQLDAYYNMKRVD

Download         Length: 363 bp

>AT243338 NZ_OW970555:c49867-49637 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGTGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAACGCGAGGATGTGGTCAGCGACGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A0UEJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A0A1GRX0

References