Detailed information of TA system TA243337

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 449231..449884
• Replicon: chromosome
• Accession: NZ_CP096768
• Organism: Acinetobacter baumannii strain 5388

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: M1S47_RS02180
• Protein ID: WP_000607077.1
• Coordinates: 449495..449884 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: M1S47_RS02175
• Protein ID: WP_001288210.1
• Coordinates: 449231..449488 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1S47_RS02155 (M1S47_02155)	444747..445754	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
M1S47_RS02160 (M1S47_02160)	445773..446150	+	378	WP_001216380.1	50S ribosomal protein L17	-
M1S47_RS02165 (M1S47_02165)	446332..447822	+	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
M1S47_RS02170 (M1S47_02170)	447871..449043	-	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
M1S47_RS02175 (M1S47_02175)	449231..449488	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
M1S47_RS02180 (M1S47_02180)	449495..449884	+	390	WP_000607077.1	membrane protein	Toxin
M1S47_RS02185 (M1S47_02185)	450654..451739	+	1086	WP_000049106.1	hypothetical protein	-
M1S47_RS02190 (M1S47_02190)	451817..452383	+	567	WP_000651538.1	rhombosortase	-
M1S47_RS02195 (M1S47_02195)	452571..454766	+	2196	WP_001158906.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T243337 WP_000607077.1 NZ_CP096768:449495-449884 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T243337 NZ_OW970554:c116598-116293 [Klebsiella pneumoniae]
ATGCAGTTCACCGTCTACGAATACACACGCGAGAGCCATTATCGTCTTTTTGTGGATGTGCAGAGCGACATTGTCGAGAC
GCCTGGGCGACGCATAGTGATCCCGTTGCTGGAATCGCACCACTTATCAGAAAAGGTTAATCAGCAGCTTTTCCCGGTGG
TTAGCGTCAATGGGAAAGAATACCGTGCCGTGACTTCCGAATTATCCGGAGTCTCTGTCAGTGTCATCGGCGACGCTGTG
GCCGATCTCAGCCATGAGGCAAATGCCATTAAAAATGCCCTGAACCTGATGTTCTGGGGCATTTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT243337 WP_001288210.1 NZ_CP096768:449231-449488 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT243337 NZ_OW970554:c116816-116598 [Klebsiella pneumoniae]
ATGAAACACAGAGCCAGCGTCACAGTAGACAAGGAACATTATCTGGAATTACTCGCGGCAGGCGTGAATATTTCGGGACT
GGTGAATGAGGCTATCGGACGGGAAGCCCGGCGCATCCAGGCTGAACGCTGGAAAGCAGAGAACCGGGAAGGGATGGAAG
AGGTAGCGAATTTCATCGCGCAGCACGGCTCTTTTGCCGACGAAAACCGGAGCTGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7