Detailed information of TA system TA243336

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1634241..1634920
• Replicon: chromosome
• Accession: NZ_CP096766
• Organism: Acinetobacter baumannii strain 5626

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: M1S35_RS07915
• Protein ID: WP_000838146.1
• Coordinates: 1634241..1634423 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: M1S35_RS07920
• Protein ID: WP_000966688.1
• Coordinates: 1634516..1634920 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1S35_RS07880 (M1S35_07880)	1629570..1629938	+	369	WP_002055488.1	hypothetical protein	-
M1S35_RS07885 (M1S35_07885)	1629940..1630338	+	399	WP_001251850.1	phage tail terminator-like protein	-
M1S35_RS07890 (M1S35_07890)	1630340..1630558	+	219	WP_001277687.1	hypothetical protein	-
M1S35_RS07895 (M1S35_07895)	1630652..1631005	+	354	WP_000064599.1	hypothetical protein	-
M1S35_RS07900 (M1S35_07900)	1631005..1632360	+	1356	WP_038345386.1	hypothetical protein	-
M1S35_RS07905 (M1S35_07905)	1632413..1633330	+	918	WP_024435783.1	phage tail tube protein	-
M1S35_RS07910 (M1S35_07910)	1633400..1633915	+	516	WP_017817058.1	hypothetical protein	-
M1S35_RS07915 (M1S35_07915)	1634241..1634423	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
M1S35_RS07920 (M1S35_07920)	1634516..1634920	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
M1S35_RS07930 (M1S35_07930)	1636209..1636718	+	510	WP_000734512.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1602672..1656583	53911

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T243336 WP_000838146.1 NZ_CP096766:1634241-1634423 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T243336 NZ_OW970553:c5242811-5242428 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT243336 WP_000966688.1 NZ_CP096766:1634516-1634920 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT243336 NZ_OW970553:c5243053-5242811 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6