Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3944808..3945462 Replicon chromosome
Accession NC_013361
Organism Escherichia coli O26:H11 str. 11368

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag ECO26_RS20870 Protein ID WP_000244777.1
Coordinates 3944808..3945215 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag ECO26_RS20875 Protein ID WP_000354046.1
Coordinates 3945196..3945462 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECO26_RS20850 3940765..3942498 - 1734 WP_000813220.1 single-stranded-DNA-specific exonuclease RecJ -
ECO26_RS20855 3942504..3943214 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ECO26_RS20860 3943239..3944135 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
ECO26_RS20865 3944247..3944768 + 522 WP_001055874.1 flavodoxin FldB -
ECO26_RS20870 3944808..3945215 - 408 WP_000244777.1 toxin CptA Toxin
ECO26_RS20875 3945196..3945462 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
ECO26_RS20880 3945705..3946685 + 981 WP_000886095.1 tRNA-modifying protein YgfZ -
ECO26_RS20885 3946881..3947540 - 660 WP_000250274.1 hemolysin III family protein -
ECO26_RS20890 3947704..3948015 - 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
ECO26_RS20895 3948060..3949493 + 1434 WP_000737106.1 6-phospho-beta-glucosidase BglA -
ECO26_RS20900 3949550..3950293 - 744 WP_000951964.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T24333 WP_000244777.1 NC_013361:c3945215-3944808 [Escherichia coli O26:H11 str. 11368]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T24333 NC_013361:c3945215-3944808 [Escherichia coli O26:H11 str. 11368]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT24333 WP_000354046.1 NC_013361:c3945462-3945196 [Escherichia coli O26:H11 str. 11368]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT24333 NC_013361:c3945462-3945196 [Escherichia coli O26:H11 str. 11368]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References