Detailed information of TA system TA243326

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3346239..3346921
• Replicon: chromosome
• Accession: NZ_CP096755
• Organism: Acinetobacter baumannii strain 5663

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: M1S57_RS16215
• Protein ID: WP_000009390.1
• Coordinates: 3346239..3346418 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A1S2G1M8
• Locus tag: M1S57_RS16220
• Protein ID: WP_000878688.1
• Coordinates: 3346508..3346921 (+)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1S57_RS16195 (M1S57_16195)	3342035..3342895	-	861	WP_071211542.1	GPO family capsid scaffolding protein	-
M1S57_RS16200 (M1S57_16200)	3343073..3344851	+	1779	WP_071211543.1	terminase family protein	-
M1S57_RS16205 (M1S57_16205)	3344848..3345897	+	1050	WP_062936692.1	phage portal protein	-
M1S57_RS16210 (M1S57_16210)	3345907..3346122	+	216	WP_071211544.1	hypothetical protein	-
M1S57_RS16215 (M1S57_16215)	3346239..3346418	+	180	WP_000009390.1	type II toxin-antitoxin system HicA family toxin	Toxin
M1S57_RS16220 (M1S57_16220)	3346508..3346921	+	414	WP_000878688.1	hypothetical protein	Antitoxin
M1S57_RS16225 (M1S57_16225)	3347190..3348044	-	855	WP_071211545.1	SH3 domain-containing protein	-
M1S57_RS16250 (M1S57_16250)	3349175..3350239	-	1065	WP_001278262.1	quinolinate synthase NadA	-
M1S57_RS16255 (M1S57_16255)	3350386..3351606	-	1221	WP_000268130.1	bifunctional glutamate N-acetyltransferase/amino-acid acetyltransferase ArgJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3308689..3346921	38232

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (10-78)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6799.11 Da
• Isoelectric Point: 11.1422

>T243326 WP_000009390.1 NZ_CP096755:3346239-3346418 [Acinetobacter baumannii]
MSFNEFKRWLIAQGVIFVRKGKGSHMIIEFNGKKTVFPNHGKKEIPEGTRLKIKKDLGL

Nucleotide

• Length: 180 bp

>T243326 NZ_OW970553:356941-357288 [Klebsiella pneumoniae]
ATGTGGGATGTGGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATAAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15511.84 Da
• Isoelectric Point: 5.2905

>AT243326 WP_000878688.1 NZ_CP096755:3346508-3346921 [Acinetobacter baumannii]
MKYYVSIVQEEGAYIVSSRDLPLLNSVGYTLEEALSEALDGIETTFEIYMDERKAIPLPSKGKKDEYEIHLPVRVAAKVR
LYNEMISQDVTKAELARRLGWLQKQADRLLSLKHSTKLESIESAFHALGKDLDIVVA

Nucleotide

• Length: 414 bp

>AT243326 NZ_OW970553:357288-357587 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGACTGATAACGACCCTCGGCTTTCGACCCTAAAAAGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A1S2G1M8