Detailed information of TA system TA243325

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 451921..452574
• Replicon: chromosome
• Accession: NZ_CP096755
• Organism: Acinetobacter baumannii strain 5663

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: M1S57_RS02195
• Protein ID: WP_000607077.1
• Coordinates: 452185..452574 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: M1S57_RS02190
• Protein ID: WP_001288210.1
• Coordinates: 451921..452178 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1S57_RS02170 (M1S57_02170)	447437..448444	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
M1S57_RS02175 (M1S57_02175)	448463..448840	+	378	WP_001216380.1	50S ribosomal protein L17	-
M1S57_RS02180 (M1S57_02180)	449022..450512	+	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
M1S57_RS02185 (M1S57_02185)	450561..451733	-	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
M1S57_RS02190 (M1S57_02190)	451921..452178	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
M1S57_RS02195 (M1S57_02195)	452185..452574	+	390	WP_000607077.1	membrane protein	Toxin
M1S57_RS02200 (M1S57_02200)	453344..454429	+	1086	WP_000049106.1	hypothetical protein	-
M1S57_RS02205 (M1S57_02205)	454507..455073	+	567	WP_000651538.1	rhombosortase	-
M1S57_RS02210 (M1S57_02210)	455261..457456	+	2196	WP_001158906.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T243325 WP_000607077.1 NZ_CP096755:452185-452574 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T243325 NZ_OW970553:330972-331340 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGACAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT243325 WP_001288210.1 NZ_CP096755:451921-452178 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT243325 NZ_OW970553:330754-330975 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7