Detailed information of TA system TA243322

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 451770..452423
• Replicon: chromosome
• Accession: NZ_CP096753
• Organism: Acinetobacter baumannii strain 5664

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: M1S46_RS02190
• Protein ID: WP_000607077.1
• Coordinates: 452034..452423 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: M1S46_RS02185
• Protein ID: WP_001288210.1
• Coordinates: 451770..452027 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1S46_RS02165 (M1S46_02165)	447286..448293	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
M1S46_RS02170 (M1S46_02170)	448312..448689	+	378	WP_001216380.1	50S ribosomal protein L17	-
M1S46_RS02175 (M1S46_02175)	448871..450361	+	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
M1S46_RS02180 (M1S46_02180)	450410..451582	-	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
M1S46_RS02185 (M1S46_02185)	451770..452027	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
M1S46_RS02190 (M1S46_02190)	452034..452423	+	390	WP_000607077.1	membrane protein	Toxin
M1S46_RS02195 (M1S46_02195)	453193..454278	+	1086	WP_000049106.1	hypothetical protein	-
M1S46_RS02200 (M1S46_02200)	454356..454922	+	567	WP_000651538.1	rhombosortase	-
M1S46_RS02205 (M1S46_02205)	455110..457305	+	2196	WP_001158906.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T243322 WP_000607077.1 NZ_CP096753:452034-452423 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T243322 NZ_OW970540:c5232524-5232141 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT243322 WP_001288210.1 NZ_CP096753:451770-452027 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT243322 NZ_OW970540:c5232766-5232524 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7