Detailed information of TA system TA243318

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 451758..452411
• Replicon: chromosome
• Accession: NZ_CP096745
• Organism: Acinetobacter baumannii strain 5670

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: M1S17_RS02200
• Protein ID: WP_000607077.1
• Coordinates: 452022..452411 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: M1S17_RS02195
• Protein ID: WP_001288210.1
• Coordinates: 451758..452015 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1S17_RS02175 (M1S17_02175)	447274..448281	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
M1S17_RS02180 (M1S17_02180)	448300..448677	+	378	WP_001216380.1	50S ribosomal protein L17	-
M1S17_RS02185 (M1S17_02185)	448859..450349	+	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
M1S17_RS02190 (M1S17_02190)	450398..451570	-	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
M1S17_RS02195 (M1S17_02195)	451758..452015	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
M1S17_RS02200 (M1S17_02200)	452022..452411	+	390	WP_000607077.1	membrane protein	Toxin
M1S17_RS02205 (M1S17_02205)	453181..454266	+	1086	WP_000049106.1	hypothetical protein	-
M1S17_RS02210 (M1S17_02210)	454344..454910	+	567	WP_000651538.1	rhombosortase	-
M1S17_RS02215 (M1S17_02215)	455098..457293	+	2196	WP_001158906.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T243318 WP_000607077.1 NZ_CP096745:452022-452411 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T243318 NZ_OW970540:4028895-4029113 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT243318 WP_001288210.1 NZ_CP096745:451758-452015 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT243318 NZ_OW970540:4028494-4028868 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7