Detailed information of TA system TA243316

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1462758..1463437
• Replicon: chromosome
• Accession: NZ_CP096742
• Organism: Acinetobacter baumannii strain 5671

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: M1S42_RS07055
• Protein ID: WP_000838146.1
• Coordinates: 1462758..1462940 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: M1S42_RS07060
• Protein ID: WP_000966688.1
• Coordinates: 1463033..1463437 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1S42_RS07015 (M1S42_07015)	1457831..1458235	+	405	WP_000247948.1	hypothetical protein	-
M1S42_RS07020 (M1S42_07020)	1458207..1458575	+	369	WP_002055488.1	hypothetical protein	-
M1S42_RS07025 (M1S42_07025)	1458577..1458975	+	399	WP_001251850.1	phage tail terminator-like protein	-
M1S42_RS07030 (M1S42_07030)	1458977..1459195	+	219	WP_001277687.1	hypothetical protein	-
M1S42_RS07035 (M1S42_07035)	1459289..1459642	+	354	WP_000064599.1	hypothetical protein	-
M1S42_RS07040 (M1S42_07040)	1459642..1460877	+	1236	WP_000002422.1	hypothetical protein	-
M1S42_RS07045 (M1S42_07045)	1460930..1461847	+	918	WP_000094250.1	phage tail tube protein	-
M1S42_RS07050 (M1S42_07050)	1461917..1462432	+	516	WP_001185608.1	hypothetical protein	-
M1S42_RS07055 (M1S42_07055)	1462758..1462940	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
M1S42_RS07060 (M1S42_07060)	1463033..1463437	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
M1S42_RS07065 (M1S42_07065)	1463536..1463712	+	177	WP_014466185.1	hypothetical protein	-
M1S42_RS07070 (M1S42_07070)	1463721..1464044	+	324	WP_000523922.1	DUF4236 domain-containing protein	-
M1S42_RS07075 (M1S42_07075)	1464076..1464870	+	795	WP_000720608.1	hypothetical protein	-
M1S42_RS07080 (M1S42_07080)	1464919..1465158	-	240	WP_000763623.1	Arc family DNA-binding protein	-
M1S42_RS07085 (M1S42_07085)	1465281..1465436	+	156	WP_001103649.1	Arc family DNA-binding protein	-
M1S42_RS07090 (M1S42_07090)	1465433..1466425	+	993	WP_000835645.1	KilA-N domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1431486..1483710	52224

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T243316 WP_000838146.1 NZ_CP096742:1462758-1462940 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T243316 NZ_OW970540:2044159-2044261 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT243316 WP_000966688.1 NZ_CP096742:1463033-1463437 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT243316 NZ_OW970540:c2044268-2044123 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6