Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 2231131..2231810 | Replicon | chromosome |
| Accession | NZ_CP096731 | ||
| Organism | Acinetobacter baumannii strain 5689 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | S3TWT7 |
| Locus tag | M1S49_RS10610 | Protein ID | WP_000838146.1 |
| Coordinates | 2231628..2231810 (-) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | N9L2H6 |
| Locus tag | M1S49_RS10605 | Protein ID | WP_000966688.1 |
| Coordinates | 2231131..2231535 (-) | Length | 135 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M1S49_RS10575 (M1S49_10575) | 2228402..2229394 | - | 993 | WP_000835645.1 | KilA-N domain-containing protein | - |
| M1S49_RS10580 (M1S49_10580) | 2229391..2229546 | - | 156 | WP_001103649.1 | Arc family DNA-binding protein | - |
| M1S49_RS10585 (M1S49_10585) | 2229669..2229908 | + | 240 | WP_000763623.1 | Arc family DNA-binding protein | - |
| M1S49_RS10590 (M1S49_10590) | 2229955..2230305 | - | 351 | WP_001227131.1 | hypothetical protein | - |
| M1S49_RS10595 (M1S49_10595) | 2230362..2230688 | - | 327 | WP_000735265.1 | hypothetical protein | - |
| M1S49_RS10600 (M1S49_10600) | 2230692..2231033 | - | 342 | WP_000720515.1 | hypothetical protein | - |
| M1S49_RS10605 (M1S49_10605) | 2231131..2231535 | - | 405 | WP_000966688.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| M1S49_RS10610 (M1S49_10610) | 2231628..2231810 | - | 183 | WP_000838146.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| M1S49_RS10615 (M1S49_10615) | 2232136..2232651 | - | 516 | WP_001185608.1 | hypothetical protein | - |
| M1S49_RS10620 (M1S49_10620) | 2232721..2233638 | - | 918 | WP_000094250.1 | phage tail tube protein | - |
| M1S49_RS10625 (M1S49_10625) | 2233691..2234845 | - | 1155 | WP_114340178.1 | phage tail protein | - |
| M1S49_RS10630 (M1S49_10630) | 2234845..2235198 | - | 354 | WP_015451444.1 | hypothetical protein | - |
| M1S49_RS10635 (M1S49_10635) | 2235267..2235665 | - | 399 | WP_000178914.1 | phage tail terminator-like protein | - |
| M1S49_RS10640 (M1S49_10640) | 2235667..2236035 | - | 369 | WP_114340181.1 | HK97 gp10 family phage protein | - |
| M1S49_RS10645 (M1S49_10645) | 2236007..2236414 | - | 408 | WP_114340179.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2213515..2263012 | 49497 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6695.84 Da Isoelectric Point: 10.5523
>T243308 WP_000838146.1 NZ_CP096731:c2231810-2231628 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN
Download Length: 183 bp
>T243308 NZ_OW970530:c5230824-5230441 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA
Antitoxin
Download Length: 135 a.a. Molecular weight: 14647.69 Da Isoelectric Point: 4.4328
>AT243308 WP_000966688.1 NZ_CP096731:c2231535-2231131 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA
Download Length: 405 bp
>AT243308 NZ_OW970530:c5231066-5230824 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|