Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1017065..1017716 Replicon chromosome
Accession NZ_CP096731
Organism Acinetobacter baumannii strain 5689

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag M1S49_RS04885 Protein ID WP_000838146.1
Coordinates 1017065..1017247 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1AAF8
Locus tag M1S49_RS04890 Protein ID WP_000966689.1
Coordinates 1017312..1017716 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1S49_RS04840 (M1S49_04840) 1012322..1012987 + 666 WP_000767881.1 Ish1 domain-containing protein -
M1S49_RS04845 (M1S49_04845) 1012992..1013381 + 390 WP_000008492.1 hypothetical protein -
M1S49_RS04850 (M1S49_04850) 1013383..1013751 + 369 WP_000524231.1 hypothetical protein -
M1S49_RS04855 (M1S49_04855) 1013760..1014164 + 405 WP_000248323.1 hypothetical protein -
M1S49_RS04860 (M1S49_04860) 1014136..1014504 + 369 WP_000539752.1 hypothetical protein -
M1S49_RS04865 (M1S49_04865) 1014506..1014904 + 399 WP_001132270.1 hypothetical protein -
M1S49_RS04870 (M1S49_04870) 1014906..1015118 + 213 WP_000121166.1 hypothetical protein -
M1S49_RS04875 (M1S49_04875) 1015226..1016155 + 930 WP_000094299.1 phage tail tube protein -
M1S49_RS04880 (M1S49_04880) 1016200..1016733 + 534 WP_001185622.1 hypothetical protein -
M1S49_RS04885 (M1S49_04885) 1017065..1017247 + 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
M1S49_RS04890 (M1S49_04890) 1017312..1017716 + 405 WP_000966689.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
M1S49_RS04895 (M1S49_04895) 1017797..1018198 + 402 WP_000720591.1 hypothetical protein -
M1S49_RS04900 (M1S49_04900) 1018259..1022224 + 3966 WP_000191304.1 tape measure protein -
M1S49_RS04905 (M1S49_04905) 1022342..1022683 + 342 WP_001281459.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 986672..1041287 54615


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T243307 WP_000838146.1 NZ_CP096731:1017065-1017247 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T243307 NZ_OW970530:c4919149-4918274 [Klebsiella pneumoniae]
ATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATTTGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGA
TTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGGTGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGG
ATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAGGCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAG
ATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAAGATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACC
ACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTTTTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCT
ACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCATCCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAG
GAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTATTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCC
TCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAATTCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGA
CAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCCTGTATCACACAACAGGATGTCGATTTTTTACTGTCATTTAAA
CGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCGTATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATAT
TCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAGATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14769.78 Da        Isoelectric Point: 4.5000

>AT243307 WP_000966689.1 NZ_CP096731:1017312-1017716 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT243307 NZ_OW970530:c4919955-4919197 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1AAF8

References