Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1603640..1604319 Replicon chromosome
Accession NZ_CP096722
Organism Acinetobacter baumannii strain 5736

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag M1S25_RS07690 Protein ID WP_000838146.1
Coordinates 1603640..1603822 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID N9L2H6
Locus tag M1S25_RS07695 Protein ID WP_000966688.1
Coordinates 1603915..1604319 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1S25_RS07650 (M1S25_07650) 1598713..1599117 + 405 WP_000247948.1 hypothetical protein -
M1S25_RS07655 (M1S25_07655) 1599089..1599457 + 369 WP_002055488.1 hypothetical protein -
M1S25_RS07660 (M1S25_07660) 1599459..1599857 + 399 WP_001251850.1 phage tail terminator-like protein -
M1S25_RS07665 (M1S25_07665) 1599859..1600077 + 219 WP_001277687.1 hypothetical protein -
M1S25_RS07670 (M1S25_07670) 1600171..1600524 + 354 WP_000064599.1 hypothetical protein -
M1S25_RS07675 (M1S25_07675) 1600524..1601759 + 1236 WP_024435418.1 hypothetical protein -
M1S25_RS07680 (M1S25_07680) 1601812..1602729 + 918 WP_000094270.1 phage tail tube protein -
M1S25_RS07685 (M1S25_07685) 1602799..1603314 + 516 WP_001185608.1 hypothetical protein -
M1S25_RS07690 (M1S25_07690) 1603640..1603822 + 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
M1S25_RS07695 (M1S25_07695) 1603915..1604319 + 405 WP_000966688.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
M1S25_RS07700 (M1S25_07700) 1604418..1604936 + 519 WP_004793706.1 DUF4468 domain-containing protein -
M1S25_RS07705 (M1S25_07705) 1605001..1605501 + 501 WP_004793705.1 hypothetical protein -
M1S25_RS07710 (M1S25_07710) 1605624..1605782 + 159 WP_004793704.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1572271..1627653 55382


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T243302 WP_000838146.1 NZ_CP096722:1603640-1603822 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T243302 NZ_OW970530:2042105-2042207 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14647.69 Da        Isoelectric Point: 4.4328

>AT243302 WP_000966688.1 NZ_CP096722:1603915-1604319 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT243302 NZ_OW970530:c2042214-2042069 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB N9L2H6

References