243297

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 41271..41859 Replicon plasmid p5745_1
Accession NZ_CP096715
Organism Acinetobacter baumannii strain 5745

Toxin (Protein)


Gene name brnT Uniprot ID A0A0J8TIH5
Locus tag M1S38_RS19375 Protein ID WP_000438827.1
Coordinates 41572..41859 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag M1S38_RS19370 Protein ID WP_001983304.1
Coordinates 41271..41585 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1S38_RS19345 (M1S38_19345) 36792..37147 + 356 Protein_42 type II toxin-antitoxin system RelE/ParE family toxin -
M1S38_RS19350 (M1S38_19350) 37140..37382 + 243 Protein_43 helix-turn-helix transcriptional regulator -
M1S38_RS19355 (M1S38_19355) 37450..37640 + 191 Protein_44 hypothetical protein -
M1S38_RS19360 (M1S38_19360) 37966..38427 - 462 WP_000761346.1 DIP1984 family protein -
M1S38_RS19365 (M1S38_19365) 38732..41143 - 2412 WP_000932953.1 TonB-dependent receptor ZnuD2 -
M1S38_RS19370 (M1S38_19370) 41271..41585 - 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
M1S38_RS19375 (M1S38_19375) 41572..41859 - 288 WP_000438827.1 BrnT family toxin Toxin
M1S38_RS19380 (M1S38_19380) 42127..42426 - 300 WP_000358348.1 hypothetical protein -
M1S38_RS19385 (M1S38_19385) 42543..43303 - 761 Protein_50 hypothetical protein -
M1S38_RS19390 (M1S38_19390) 43604..44134 + 531 WP_249376160.1 MobA/MobL family protein -
M1S38_RS19395 (M1S38_19395) 44164..44415 + 252 WP_249376163.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..44752 44752


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11329.75 Da        Isoelectric Point: 5.6762

>T243297 WP_000438827.1 NZ_CP096715:c41859-41572 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRYTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

>T243297 NZ_OW970530:330972-331340 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGACAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT243297 WP_001983304.1 NZ_CP096715:c41585-41271 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp

>AT243297 NZ_OW970530:330754-330975 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J8TIH5

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References