243294

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 18899..19487 Replicon plasmid p5745_1
Accession NZ_CP096715
Organism Acinetobacter baumannii strain 5745

Toxin (Protein)


Gene name brnT Uniprot ID A0A0J8TIH5
Locus tag M1S38_RS19245 Protein ID WP_000438827.1
Coordinates 19200..19487 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag M1S38_RS19240 Protein ID WP_001983304.1
Coordinates 18899..19213 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1S38_RS19215 (M1S38_19215) 14416..14772 + 357 WP_000269904.1 type II toxin-antitoxin system RelE/ParE family toxin -
M1S38_RS19220 (M1S38_19220) 14765..15067 + 303 WP_001129974.1 XRE family transcriptional regulator -
M1S38_RS19225 (M1S38_19225) 15060..15269 + 210 WP_000069474.1 hypothetical protein -
M1S38_RS19230 (M1S38_19230) 15595..16056 - 462 WP_000761346.1 DIP1984 family protein -
M1S38_RS19235 (M1S38_19235) 16361..18771 - 2411 Protein_20 TonB-dependent receptor ZnuD2 -
M1S38_RS19240 (M1S38_19240) 18899..19213 - 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
M1S38_RS19245 (M1S38_19245) 19200..19487 - 288 WP_000438827.1 BrnT family toxin Toxin
M1S38_RS19250 (M1S38_19250) 19755..20054 - 300 WP_000358348.1 hypothetical protein -
M1S38_RS19255 (M1S38_19255) 20265..20783 - 519 WP_000839337.1 plasmid replication DNA-binding protein -
M1S38_RS19260 (M1S38_19260) 20861..21803 - 943 Protein_25 replication initiation protein RepM -
M1S38_RS19265 (M1S38_19265) 22400..23569 - 1170 WP_002134206.1 MobA/MobL family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..44752 44752


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11329.75 Da        Isoelectric Point: 5.6762

>T243294 WP_000438827.1 NZ_CP096715:c19487-19200 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRYTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

>T243294 NZ_OW970514:c5214562-5214179 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT243294 WP_001983304.1 NZ_CP096715:c19213-18899 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp

>AT243294 NZ_OW970514:c5214804-5214562 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J8TIH5

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References