243292

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 7705..8293 Replicon plasmid p5745_1
Accession NZ_CP096715
Organism Acinetobacter baumannii strain 5745

Toxin (Protein)


Gene name brnT Uniprot ID A0A0J8TIH5
Locus tag M1S38_RS19180 Protein ID WP_000438827.1
Coordinates 8006..8293 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag M1S38_RS19175 Protein ID WP_001983304.1
Coordinates 7705..8019 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1S38_RS19150 (M1S38_19150) 3226..3582 + 357 WP_000269904.1 type II toxin-antitoxin system RelE/ParE family toxin -
M1S38_RS19155 (M1S38_19155) 3575..3877 + 303 WP_001129974.1 XRE family transcriptional regulator -
M1S38_RS19160 (M1S38_19160) 3870..4079 + 210 WP_000069474.1 hypothetical protein -
M1S38_RS19165 (M1S38_19165) 4405..4866 - 462 WP_000761346.1 DIP1984 family protein -
M1S38_RS19170 (M1S38_19170) 5170..7577 - 2408 Protein_7 TonB-dependent receptor ZnuD2 -
M1S38_RS19175 (M1S38_19175) 7705..8019 - 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
M1S38_RS19180 (M1S38_19180) 8006..8293 - 288 WP_000438827.1 BrnT family toxin Toxin
M1S38_RS19185 (M1S38_19185) 8561..8860 - 300 WP_000358348.1 hypothetical protein -
M1S38_RS19190 (M1S38_19190) 9070..9588 - 519 WP_000839337.1 plasmid replication DNA-binding protein -
M1S38_RS19195 (M1S38_19195) 9666..10601 - 936 WP_001292329.1 replication initiation protein RepM -
M1S38_RS19200 (M1S38_19200) 11197..12174 - 978 WP_249376165.1 MobA/MobL family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..44752 44752


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11329.75 Da        Isoelectric Point: 5.6762

>T243292 WP_000438827.1 NZ_CP096715:c8293-8006 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRYTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

>T243292 NZ_OW970514:c4742441-4742157 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT243292 WP_001983304.1 NZ_CP096715:c8019-7705 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp

>AT243292 NZ_OW970514:c4742673-4742431 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J8TIH5

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References