Detailed information of TA system TA243290

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 449547..450200
• Replicon: chromosome
• Accession: NZ_CP096714
• Organism: Acinetobacter baumannii strain 5745

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: M1S38_RS02185
• Protein ID: WP_000607077.1
• Coordinates: 449811..450200 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: M1S38_RS02180
• Protein ID: WP_001288210.1
• Coordinates: 449547..449804 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1S38_RS02160 (M1S38_02160)	445063..446070	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
M1S38_RS02165 (M1S38_02165)	446089..446466	+	378	WP_001216380.1	50S ribosomal protein L17	-
M1S38_RS02170 (M1S38_02170)	446648..448138	+	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
M1S38_RS02175 (M1S38_02175)	448187..449359	-	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
M1S38_RS02180 (M1S38_02180)	449547..449804	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
M1S38_RS02185 (M1S38_02185)	449811..450200	+	390	WP_000607077.1	membrane protein	Toxin
M1S38_RS02190 (M1S38_02190)	450970..452055	+	1086	WP_000049106.1	hypothetical protein	-
M1S38_RS02195 (M1S38_02195)	452133..452699	+	567	WP_000651538.1	rhombosortase	-
M1S38_RS02200 (M1S38_02200)	452887..455082	+	2196	WP_001158906.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T243290 WP_000607077.1 NZ_CP096714:449811-450200 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T243290 NZ_OW970514:4010933-4011151 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT243290 WP_001288210.1 NZ_CP096714:449547-449804 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT243290 NZ_OW970514:4010532-4010906 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7