Detailed information of TA system TA243285

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1613821..1614500
• Replicon: chromosome
• Accession: NZ_CP096707
• Organism: Acinetobacter baumannii strain 5760

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: M1S43_RS07740
• Protein ID: WP_000838146.1
• Coordinates: 1613821..1614003 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: M1S43_RS07745
• Protein ID: WP_000966688.1
• Coordinates: 1614096..1614500 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1S43_RS07705 (M1S43_07705)	1609185..1609553	+	369	WP_038340144.1	hypothetical protein	-
M1S43_RS07710 (M1S43_07710)	1609555..1609953	+	399	WP_038340137.1	phage tail terminator-like protein	-
M1S43_RS07715 (M1S43_07715)	1609955..1610173	+	219	WP_038340131.1	hypothetical protein	-
M1S43_RS07720 (M1S43_07720)	1610232..1610585	+	354	WP_000064601.1	hypothetical protein	-
M1S43_RS07725 (M1S43_07725)	1610585..1611940	+	1356	WP_038345386.1	hypothetical protein	-
M1S43_RS07730 (M1S43_07730)	1611993..1612910	+	918	WP_024435783.1	phage tail tube protein	-
M1S43_RS07735 (M1S43_07735)	1612980..1613495	+	516	WP_017817058.1	hypothetical protein	-
M1S43_RS07740 (M1S43_07740)	1613821..1614003	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
M1S43_RS07745 (M1S43_07745)	1614096..1614500	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
M1S43_RS07750 (M1S43_07750)	1614598..1615687	-	1090	Protein_1503	IS4-like element ISAba1 family transposase	-
M1S43_RS07755 (M1S43_07755)	1615788..1616297	+	510	WP_000734512.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1579144..1636163	57019

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T243285 WP_000838146.1 NZ_CP096707:1613821-1614003 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T243285 NZ_OW970514:835139-835549 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT243285 WP_000966688.1 NZ_CP096707:1614096-1614500 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT243285 NZ_OW970514:834892-835158 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6