Detailed information of TA system TA243280

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1598204..1598883
• Replicon: chromosome
• Accession: NZ_CP096702
• Organism: Acinetobacter baumannii strain 5767

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: M1S32_RS07670
• Protein ID: WP_000838146.1
• Coordinates: 1598204..1598386 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: M1S32_RS07675
• Protein ID: WP_000966688.1
• Coordinates: 1598479..1598883 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1S32_RS07635 (M1S32_07635)	1593568..1593936	+	369	WP_038340144.1	hypothetical protein	-
M1S32_RS07640 (M1S32_07640)	1593938..1594336	+	399	WP_038340137.1	phage tail terminator-like protein	-
M1S32_RS07645 (M1S32_07645)	1594338..1594556	+	219	WP_038340131.1	hypothetical protein	-
M1S32_RS07650 (M1S32_07650)	1594615..1594968	+	354	WP_000064601.1	hypothetical protein	-
M1S32_RS07655 (M1S32_07655)	1594968..1596323	+	1356	WP_038345386.1	hypothetical protein	-
M1S32_RS07660 (M1S32_07660)	1596376..1597293	+	918	WP_024435783.1	phage tail tube protein	-
M1S32_RS07665 (M1S32_07665)	1597363..1597878	+	516	WP_017817058.1	hypothetical protein	-
M1S32_RS07670 (M1S32_07670)	1598204..1598386	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
M1S32_RS07675 (M1S32_07675)	1598479..1598883	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
M1S32_RS07680 (M1S32_07680)	1598982..1599500	+	519	WP_004793706.1	DUF4468 domain-containing protein	-
M1S32_RS07685 (M1S32_07685)	1599565..1600065	+	501	WP_004793705.1	hypothetical protein	-
M1S32_RS07690 (M1S32_07690)	1600188..1600346	+	159	WP_004793704.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1566540..1620152	53612

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T243280 WP_000838146.1 NZ_CP096702:1598204-1598386 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T243280 NZ_CP096702:1598204-1598386 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT243280 WP_000966688.1 NZ_CP096702:1598479-1598883 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT243280 NZ_CP096702:1598479-1598883 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6