Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2829775..2830610 Replicon chromosome
Accession NC_013361
Organism Escherichia coli O26:H11 str. 11368

Toxin (Protein)


Gene name yeeV Uniprot ID A0A136X5A2
Locus tag ECO26_RS15235 Protein ID WP_000854757.1
Coordinates 2830233..2830610 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag ECO26_RS15230 Protein ID WP_001295723.1
Coordinates 2829775..2830143 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECO26_RS15185 2825882..2826229 - 348 WP_000612626.1 IS66 family insertion sequence element accessory protein TnpB -
ECO26_RS15190 2826226..2826630 - 405 WP_000839179.1 IS66 family insertion sequence hypothetical protein -
ECO26_RS15195 2826719..2827060 + 342 WP_072097794.1 hypothetical protein -
ECO26_RS15200 2827139..2827372 + 234 WP_001119729.1 DUF905 family protein -
ECO26_RS15205 2827472..2828290 + 819 WP_001234620.1 DUF945 domain-containing protein -
ECO26_RS15210 2828345..2828830 + 486 WP_000849582.1 antirestriction protein -
ECO26_RS15215 2828846..2829322 + 477 WP_001186725.1 RadC family protein -
ECO26_RS15220 2829391..2829612 + 222 WP_000692323.1 DUF987 domain-containing protein -
ECO26_RS15230 2829775..2830143 + 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
ECO26_RS15235 2830233..2830610 + 378 WP_000854757.1 TA system toxin CbtA family protein Toxin
ECO26_RS15240 2830607..2830810 + 204 WP_000761705.1 hypothetical protein -
ECO26_RS34720 2830823..2830936 + 114 WP_001161660.1 DUF957 domain-containing protein -
ECO26_RS35030 2831752..2832123 + 372 WP_001295631.1 IS110 family transposase -
ECO26_RS15260 2832577..2832759 + 183 WP_024167529.1 ethanolamine utilization protein -
ECO26_RS15265 2832860..2833189 - 330 WP_000450409.1 DUF496 family protein -
ECO26_RS15270 2833361..2834419 - 1059 WP_001200887.1 FUSC family protein -
ECO26_RS15275 2834617..2835090 - 474 WP_001105384.1 DNA gyrase inhibitor SbmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14153.18 Da        Isoelectric Point: 7.3249

>T24328 WP_000854757.1 NC_013361:2830233-2830610 [Escherichia coli O26:H11 str. 11368]
MKTLPDTHVREVSCCPSLVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T24328 NC_013361:2830233-2830610 [Escherichia coli O26:H11 str. 11368]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCTCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAACAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT24328 WP_001295723.1 NC_013361:2829775-2830143 [Escherichia coli O26:H11 str. 11368]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT24328 NC_013361:2829775-2830143 [Escherichia coli O26:H11 str. 11368]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A136X5A2

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References