243275

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 18547..19135 Replicon plasmid p5773_1
Accession NZ_CP096694
Organism Acinetobacter baumannii strain 5773

Toxin (Protein)


Gene name brnT Uniprot ID A0A0J8TIH5
Locus tag M1S18_RS19240 Protein ID WP_000438827.1
Coordinates 18848..19135 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag M1S18_RS19235 Protein ID WP_001983304.1
Coordinates 18547..18861 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1S18_RS19210 (M1S18_19210) 14061..14417 + 357 WP_000269904.1 type II toxin-antitoxin system RelE/ParE family toxin -
M1S18_RS19215 (M1S18_19215) 14410..14712 + 303 WP_001129974.1 XRE family transcriptional regulator -
M1S18_RS19220 (M1S18_19220) 14705..14914 + 210 WP_000069474.1 hypothetical protein -
M1S18_RS19225 (M1S18_19225) 15240..15702 - 463 Protein_20 DIP1984 family protein -
M1S18_RS19230 (M1S18_19230) 16007..18419 - 2413 Protein_21 TonB-dependent receptor ZnuD2 -
M1S18_RS19235 (M1S18_19235) 18547..18861 - 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
M1S18_RS19240 (M1S18_19240) 18848..19135 - 288 WP_000438827.1 BrnT family toxin Toxin
M1S18_RS19245 (M1S18_19245) 19403..19702 - 300 WP_000358348.1 hypothetical protein -
M1S18_RS19250 (M1S18_19250) 19819..20580 - 762 WP_000425105.1 hypothetical protein -
M1S18_RS19255 (M1S18_19255) 20885..21418 + 534 WP_249377533.1 MobA/MobL family protein -
M1S18_RS19260 (M1S18_19260) 21448..22056 + 609 WP_249377534.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..22354 22354


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11329.75 Da        Isoelectric Point: 5.6762

>T243275 WP_000438827.1 NZ_CP096694:c19135-18848 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRYTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

>T243275 NZ_OW970492:2054827-2054929 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT243275 WP_001983304.1 NZ_CP096694:c18861-18547 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp

>AT243275 NZ_OW970492:c2054936-2054791 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J8TIH5

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References