Detailed information of TA system TA243271

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 448421..449074
• Replicon: chromosome
• Accession: NZ_CP096692
• Organism: Acinetobacter baumannii strain 5779

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: M1S33_RS02180
• Protein ID: WP_000607077.1
• Coordinates: 448685..449074 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: M1S33_RS02175
• Protein ID: WP_001288210.1
• Coordinates: 448421..448678 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1S33_RS02155 (M1S33_02155)	443937..444944	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
M1S33_RS02160 (M1S33_02160)	444963..445340	+	378	WP_001216380.1	50S ribosomal protein L17	-
M1S33_RS02165 (M1S33_02165)	445522..447012	+	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
M1S33_RS02170 (M1S33_02170)	447061..448233	-	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
M1S33_RS02175 (M1S33_02175)	448421..448678	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
M1S33_RS02180 (M1S33_02180)	448685..449074	+	390	WP_000607077.1	membrane protein	Toxin
M1S33_RS02185 (M1S33_02185)	449844..450929	+	1086	WP_000049106.1	hypothetical protein	-
M1S33_RS02190 (M1S33_02190)	451007..451573	+	567	WP_000651538.1	rhombosortase	-
M1S33_RS02195 (M1S33_02195)	451761..453956	+	2196	WP_001158906.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T243271 WP_000607077.1 NZ_CP096692:448685-449074 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T243271 NZ_OW970492:357717-358064 [Klebsiella pneumoniae]
ATGTGGGATGTGGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATAAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT243271 WP_001288210.1 NZ_CP096692:448421-448678 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT243271 NZ_OW970492:358064-358363 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGACTGATAACGACCCTCGGCTTTCGACCCTAAAAAGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7