Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1191185..1191836 Replicon chromosome
Accession NZ_CP096690
Organism Acinetobacter baumannii strain 5839

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag M1S54_RS05625 Protein ID WP_000838146.1
Coordinates 1191185..1191367 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1AAF8
Locus tag M1S54_RS05630 Protein ID WP_000966689.1
Coordinates 1191432..1191836 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1S54_RS05580 (M1S54_05580) 1186442..1187107 + 666 WP_000767881.1 Ish1 domain-containing protein -
M1S54_RS05585 (M1S54_05585) 1187112..1187501 + 390 WP_000008492.1 hypothetical protein -
M1S54_RS05590 (M1S54_05590) 1187503..1187871 + 369 WP_000524231.1 hypothetical protein -
M1S54_RS05595 (M1S54_05595) 1187880..1188284 + 405 WP_000248324.1 hypothetical protein -
M1S54_RS05600 (M1S54_05600) 1188256..1188624 + 369 WP_000539752.1 hypothetical protein -
M1S54_RS05605 (M1S54_05605) 1188626..1189024 + 399 WP_001132270.1 hypothetical protein -
M1S54_RS05610 (M1S54_05610) 1189026..1189238 + 213 WP_000121166.1 hypothetical protein -
M1S54_RS05615 (M1S54_05615) 1189346..1190275 + 930 WP_000094300.1 phage tail tube protein -
M1S54_RS05620 (M1S54_05620) 1190320..1190853 + 534 WP_001185622.1 hypothetical protein -
M1S54_RS05625 (M1S54_05625) 1191185..1191367 + 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
M1S54_RS05630 (M1S54_05630) 1191432..1191836 + 405 WP_000966689.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
M1S54_RS05635 (M1S54_05635) 1191932..1192450 + 519 WP_053530939.1 DUF4468 domain-containing protein -
M1S54_RS05640 (M1S54_05640) 1192547..1196515 + 3969 WP_000191303.1 tape measure protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1162671..1212893 50222


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T243269 WP_000838146.1 NZ_CP096690:1191185-1191367 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T243269 NZ_OW970487:c116566-116261 [Klebsiella pneumoniae]
ATGCAGTTCACCGTCTACGAATACACACGCGAGAGCCATTATCGTCTTTTTGTGGATGTGCAGAGCGACATTGTCGAGAC
GCCTGGGCGACGCATAGTGATCCCGTTGCTGGAATCGCACCACTTATCAGAAAAGGTTAATCAGCAGCTTTTCCCGGTGG
TTAGCGTCAATGGGAAAGAATACCGTGCCGTGACTTCCGAATTATCCGGAGTCTCTGTCAGTGTCATCGGCGACGCTGTG
GCCGATCTCAGCCATGAGGCAAATGCCATTAAAAATGCCCTGAACCTGATGTTCTGGGGCATTTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14769.78 Da        Isoelectric Point: 4.5000

>AT243269 WP_000966689.1 NZ_CP096690:1191432-1191836 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT243269 NZ_OW970487:c116784-116566 [Klebsiella pneumoniae]
ATGAAACACAGAGCCAGCGTCACAGTAGACAAGGAACATTATCTGGAATTACTCGCGGCAGGCGTGAATATTTCGGGACT
GGTGAATGAGGCTATCGGACGGGAAGCCCGGCGCATCCAGGCTGAACGCTGGAAAGCAGAGAACCGGGAAGGGATGGAAG
AGGTAGCGAATTTCATCGCGCAGCACGGCTCTTTTGCCGACGAAAACCGGAGCTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1AAF8

References