Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 478238..478891 Replicon chromosome
Accession NZ_CP096684
Organism Acinetobacter baumannii strain 5847

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag M1S52_RS02310 Protein ID WP_000607077.1
Coordinates 478502..478891 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag M1S52_RS02305 Protein ID WP_001288210.1
Coordinates 478238..478495 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1S52_RS02285 (M1S52_02285) 473754..474761 + 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -
M1S52_RS02290 (M1S52_02290) 474780..475157 + 378 WP_001216380.1 50S ribosomal protein L17 -
M1S52_RS02295 (M1S52_02295) 475339..476829 + 1491 WP_000415125.1 NAD(P)/FAD-dependent oxidoreductase -
M1S52_RS02300 (M1S52_02300) 476878..478050 - 1173 WP_001190542.1 acyl-CoA dehydrogenase family protein -
M1S52_RS02305 (M1S52_02305) 478238..478495 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
M1S52_RS02310 (M1S52_02310) 478502..478891 + 390 WP_000607077.1 membrane protein Toxin
M1S52_RS02315 (M1S52_02315) 479661..480746 + 1086 WP_000049106.1 hypothetical protein -
M1S52_RS02320 (M1S52_02320) 480824..481390 + 567 WP_000651538.1 rhombosortase -
M1S52_RS02325 (M1S52_02325) 481578..483773 + 2196 WP_001158906.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15552.88 Da        Isoelectric Point: 10.4313

>T243263 WP_000607077.1 NZ_CP096684:478502-478891 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T243263 NZ_OW970486:2050932-2051034 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT243263 WP_001288210.1 NZ_CP096684:478238-478495 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT243263 NZ_OW970486:c2051041-2050896 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References