243261

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 2606..3194 Replicon plasmid p5955
Accession NZ_CP096683
Organism Acinetobacter baumannii strain 5955

Toxin (Protein)


Gene name brnT Uniprot ID A0A0J8TIH5
Locus tag M1S44_RS19690 Protein ID WP_000438827.1
Coordinates 2606..2893 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag M1S44_RS19695 Protein ID WP_001983304.1
Coordinates 2880..3194 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1S44_RS19675 (M1S44_19675) 299..1234 + 936 WP_001292329.1 replication initiation protein RepM -
M1S44_RS19680 (M1S44_19680) 1312..1830 + 519 WP_000839337.1 plasmid replication DNA-binding protein -
M1S44_RS19685 (M1S44_19685) 2040..2339 + 300 WP_000358348.1 hypothetical protein -
M1S44_RS19690 (M1S44_19690) 2606..2893 + 288 WP_000438827.1 BrnT family toxin Toxin
M1S44_RS19695 (M1S44_19695) 2880..3194 + 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
M1S44_RS19700 (M1S44_19700) 3322..5731 + 2410 Protein_5 TonB-dependent receptor ZnuD2 -
M1S44_RS19705 (M1S44_19705) 6037..6495 + 459 Protein_6 DIP1984 family protein -
M1S44_RS19710 (M1S44_19710) 6817..7025 - 209 Protein_7 hypothetical protein -
M1S44_RS19715 (M1S44_19715) 7018..7320 - 303 WP_001129974.1 XRE family transcriptional regulator -
M1S44_RS19720 (M1S44_19720) 7313..7670 - 358 Protein_9 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..22367 22367


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11329.75 Da        Isoelectric Point: 5.6762

>T243261 WP_000438827.1 NZ_CP096683:2606-2893 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRYTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

>T243261 NZ_OW970486:1496629-1497045 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATTATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACCGACATCCGGGTGGCGCTGCACCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGCCACGCCATCGCGGCGGGCGCCGTCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTGCCTGGACTGACACTGG
AAGACTGGGTTATTTAG

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT243261 WP_001983304.1 NZ_CP096683:2880-3194 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp

>AT243261 NZ_OW970486:1496402-1496632 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAACGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J8TIH5

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References