Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 3267572..3268110 Replicon chromosome
Accession NZ_CP096670
Organism Agarivorans sp. TSD2052

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag M0C34_RS14825 Protein ID WP_248712453.1
Coordinates 3267811..3268110 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag M0C34_RS14820 Protein ID WP_248712452.1
Coordinates 3267572..3267814 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M0C34_RS14800 (M0C34_14800) 3262666..3264531 - 1866 WP_248712448.1 VWA domain-containing protein -
M0C34_RS14805 (M0C34_14805) 3264661..3265209 - 549 WP_248712449.1 histidine phosphatase family protein -
M0C34_RS14810 (M0C34_14810) 3265425..3266420 - 996 WP_248712450.1 branched-chain amino acid aminotransferase -
M0C34_RS14815 (M0C34_14815) 3266812..3267129 - 318 WP_248712451.1 hypothetical protein -
M0C34_RS14820 (M0C34_14820) 3267572..3267814 + 243 WP_248712452.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
M0C34_RS14825 (M0C34_14825) 3267811..3268110 + 300 WP_248712453.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M0C34_RS14830 (M0C34_14830) 3268579..3268965 - 387 WP_248712454.1 hypothetical protein -
M0C34_RS14835 (M0C34_14835) 3269062..3269547 - 486 WP_248712455.1 hypothetical protein -
M0C34_RS14840 (M0C34_14840) 3269645..3270124 - 480 WP_248712456.1 hypothetical protein -
M0C34_RS14845 (M0C34_14845) 3270673..3271665 - 993 WP_248712457.1 transposase -
M0C34_RS14850 (M0C34_14850) 3271645..3272316 + 672 WP_248712458.1 transposase -
M0C34_RS14855 (M0C34_14855) 3272734..3272970 - 237 WP_248712459.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-92)

Antitoxin

Antitoxin ParD

(4-71)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11526.32 Da        Isoelectric Point: 10.1013

>T243258 WP_248712453.1 NZ_CP096670:3267811-3268110 [Agarivorans sp. TSD2052]
MKPFTLTISAKNDLKDVAIFTARRWGKEQRNIYLKQFDDSFWLLAENPDIGKGCDEIRNGYRKFLQGSHVIFYKQTGSQQ
IQIMRILHKSMDISPIFGA

Download         Length: 300 bp

>T243258 NZ_OW970486:330972-331340 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGACAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8908.73 Da        Isoelectric Point: 4.3077

>AT243258 WP_248712452.1 NZ_CP096670:3267572-3267814 [Agarivorans sp. TSD2052]
MAKNTSITLGDHFEGFISSQIQSGRYGSTSEVIRSALRLLETQETKLHTLRNSLIEGEESGVADYDLDSFINELDNENSK

Download         Length: 243 bp

>AT243258 NZ_OW970486:330754-330975 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References