Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-CC2985 |
| Location | 42291..42825 | Replicon | plasmid unnamed2 |
| Accession | NZ_CP096669 | ||
| Organism | Yersinia pestis EV76-CN | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | Q663N8 |
| Locus tag | M0M60_RS21780 | Protein ID | WP_002213360.1 |
| Coordinates | 42291..42590 (-) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | Q9ZGW3 |
| Locus tag | M0M60_RS21785 | Protein ID | WP_002224342.1 |
| Coordinates | 42583..42825 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M0M60_RS21750 (M0M60_21725) | 37980..39002 | + | 1023 | WP_000255944.1 | IS21-like element IS100 family transposase | - |
| M0M60_RS21755 (M0M60_21730) | 38999..39781 | + | 783 | WP_001317493.1 | IS21-like element IS100kyp family helper ATPase IstB | - |
| M0M60_RS21760 (M0M60_21735) | 39848..40096 | - | 249 | Protein_55 | IS21 family transposase | - |
| M0M60_RS21765 (M0M60_21740) | 40199..40843 | + | 645 | Protein_56 | IS3 family transposase | - |
| M0M60_RS21770 (M0M60_21745) | 40906..41298 | - | 393 | WP_002213403.1 | type III secretion system chaperone SycE/YerA | - |
| M0M60_RS21775 (M0M60_21750) | 41492..42151 | + | 660 | WP_002229754.1 | type III secretion system effector GTPase activator YopE | - |
| M0M60_RS21780 (M0M60_21755) | 42291..42590 | - | 300 | WP_002213360.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| M0M60_RS21785 (M0M60_21760) | 42583..42825 | - | 243 | WP_002224342.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| M0M60_RS21790 (M0M60_21765) | 42991..43283 | - | 293 | Protein_61 | transposase | - |
| M0M60_RS21795 (M0M60_21770) | 43369..43542 | + | 174 | WP_002213357.1 | hypothetical protein | - |
| M0M60_RS21800 (M0M60_21775) | 43691..43927 | - | 237 | WP_154020274.1 | hypothetical protein | - |
| M0M60_RS21805 (M0M60_21780) | 44087..45052 | - | 966 | WP_002213354.1 | ParB/RepB/Spo0J family plasmid partition protein | - |
| M0M60_RS21810 (M0M60_21785) | 45049..46215 | - | 1167 | WP_002220902.1 | plasmid-partitioning protein SopA | - |
| M0M60_RS21815 (M0M60_21790) | 46683..46896 | + | 214 | Protein_66 | IS481 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | yscS / yscT / yscU / yscU / virG/yscW / yscB / yscC / yscD / yscE / yscF / yscG / yopR/yscH/lcrP / lcrO/yscI / ylpB/yscJ / yscK / yscL / lcrQ/yscM / yopH / yopJ/yopP / yopO/ypkA / yadA / yadA / sycH / sycE/yerA / yopE / yopK/yopQ / yopT / sycT / yopM / yopD / yopB / sycD/lcrH / lcrV / lcrG / lcrR / yscV/lcrD / yscY / yscX / sycN / tyeA / lcrE/yopN / yscN / yscO / yscP / yscQ | 1..70300 | 70300 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11632.19 Da Isoelectric Point: 5.5114
>T243257 WP_002213360.1 NZ_CP096669:c42590-42291 [Yersinia pestis EV76-CN]
VYKLSELADEDIYNIASYTIRHFGVTQAKLYHENLAKVFELLAKNPELGAECNWICSDIRRFQYKKHGIYYITLSNDILI
SRVLHQSIDIDVQDFPEHE
VYKLSELADEDIYNIASYTIRHFGVTQAKLYHENLAKVFELLAKNPELGAECNWICSDIRRFQYKKHGIYYITLSNDILI
SRVLHQSIDIDVQDFPEHE
Download Length: 300 bp
>T243257 NZ_OW970481:33413-33829 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGTGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCGTGGGACCGGGCT
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGCACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGACACGCCATCGCGGCGGGCGCCATCCTGGTGACGAATAATACAAGAGAGTTTGCGCGGGTCCCGGGCCTGGTGCTGG
AAGACTGGGTGAATTAA
ATGAAGAAAACCTGGATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGTGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCGTGGGACCGGGCT
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGCACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGACACGCCATCGCGGCGGGCGCCATCCTGGTGACGAATAATACAAGAGAGTTTGCGCGGGTCCCGGGCCTGGTGCTGG
AAGACTGGGTGAATTAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8865.15 Da Isoelectric Point: 6.4781
>AT243257 WP_002224342.1 NZ_CP096669:c42825-42583 [Yersinia pestis EV76-CN]
MAHVTSVTLGEHLTGFVGEMIQSGRYGNISEVLRDALRLMEAREQRVQHVRDMVLAGTNVPVSHRLMDEIFSAAVKDTSV
MAHVTSVTLGEHLTGFVGEMIQSGRYGNISEVLRDALRLMEAREQRVQHVRDMVLAGTNVPVSHRLMDEIFSAAVKDTSV
Download Length: 243 bp
>AT243257 NZ_OW970481:33186-33416 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGTGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAACGCGAGGATGTGGTCAGCGACGAAGGACGCTTTGAGCCATGA
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGTGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAACGCGAGGATGTGGTCAGCGACGAAGGACGCTTTGAGCCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q663N8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E1NQY6 |