Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3489284..3489956 Replicon chromosome
Accession NZ_CP096666
Organism Yersinia pestis EV76-CN

Toxin (Protein)


Gene name cptA Uniprot ID Q666S4
Locus tag M0M60_RS15795 Protein ID WP_002215144.1
Coordinates 3489531..3489956 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q666S3
Locus tag M0M60_RS15790 Protein ID WP_002209939.1
Coordinates 3489284..3489550 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M0M60_RS15770 (M0M60_15745) 3485141..3486244 + 1104 WP_002209943.1 hypothetical protein -
M0M60_RS15775 (M0M60_15750) 3486446..3487147 + 702 WP_002209942.1 hemolysin III family protein -
M0M60_RS15780 (M0M60_15755) 3487405..3487902 + 498 WP_002209941.1 DUF2165 family protein -
M0M60_RS15785 (M0M60_15760) 3487975..3488967 - 993 WP_002209940.1 tRNA-modifying protein YgfZ -
M0M60_RS15790 (M0M60_15765) 3489284..3489550 + 267 WP_002209939.1 FAD assembly factor SdhE Antitoxin
M0M60_RS15795 (M0M60_15770) 3489531..3489956 + 426 WP_002215144.1 protein YgfX Toxin
M0M60_RS15800 (M0M60_15775) 3489956..3490654 + 699 WP_002209937.1 two-component system response regulator CreB -
M0M60_RS15805 (M0M60_15780) 3490679..3492097 + 1419 WP_002209936.1 two-component system sensor histidine kinase CreC -
M0M60_RS15810 (M0M60_15785) 3492218..3493675 + 1458 WP_002220113.1 cell envelope integrity protein CreD -
M0M60_RS15815 (M0M60_15790) 3493765..3494283 - 519 WP_002209934.1 flavodoxin FldB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16510.43 Da        Isoelectric Point: 10.3799

>T243252 WP_002215144.1 NZ_CP096666:3489531-3489956 [Yersinia pestis EV76-CN]
VAQWRCNLRVSWHTQLFSLLAHGILVILTLVAPWPLGYTALWLVLLTLVVFECIRSQKRIKSCQGEIRLKPGNLVRWKRH
EWTVVKPPWITRYGVLLHLQQTGGHATRKRLWLSADSMSEDEWRQLCLLLRHSFESDDGTM

Download         Length: 426 bp

>T243252 NZ_OW970478:c4653970-4653437 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10511.98 Da        Isoelectric Point: 4.6533

>AT243252 WP_002209939.1 NZ_CP096666:3489284-3489550 [Yersinia pestis EV76-CN]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDSLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELYQMVKLIQSRN
KARGPVAM

Download         Length: 267 bp

>AT243252 NZ_OW970478:c4654247-4653981 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q666S4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XP12

References