Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) /COG5642-COG5654
Location 2342323..2343289 Replicon chromosome
Accession NZ_CP096666
Organism Yersinia pestis EV76-CN

Toxin (Protein)


Gene name - Uniprot ID A0A0E8XJV6
Locus tag M0M60_RS10610 Protein ID WP_002210981.1
Coordinates 2342831..2343289 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q66A69
Locus tag M0M60_RS10605 Protein ID WP_002210982.1
Coordinates 2342323..2342769 (+) Length 149 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M0M60_RS10585 (M0M60_10570) 2337913..2338887 - 975 WP_002210985.1 L-Ala-D/L-Glu epimerase -
M0M60_RS10590 (M0M60_10575) 2339050..2339553 + 504 WP_002210984.1 thiol peroxidase -
M0M60_RS10595 (M0M60_10580) 2339806..2340264 + 459 WP_002213759.1 IS200/IS605-like element IS1541A family transposase -
M0M60_RS10600 (M0M60_10585) 2340411..2341988 - 1578 WP_002210983.1 transcriptional regulator TyrR -
M0M60_RS10605 (M0M60_10590) 2342323..2342769 + 447 WP_002210982.1 DUF2384 domain-containing protein Antitoxin
M0M60_RS10610 (M0M60_10595) 2342831..2343289 + 459 WP_002210981.1 RES family NAD+ phosphorylase Toxin
M0M60_RS10615 (M0M60_10600) 2343299..2344360 - 1062 WP_002210980.1 YcjF family protein -
M0M60_RS10620 (M0M60_10605) 2344357..2345754 - 1398 WP_002210979.1 YcjX family protein -
M0M60_RS10625 (M0M60_10610) 2345735..2345977 - 243 WP_002216375.1 phage shock protein PspD -
M0M60_RS10630 (M0M60_10615) 2346062..2346421 - 360 WP_002210977.1 envelope stress response membrane protein PspC -
M0M60_RS10635 (M0M60_10620) 2346421..2346648 - 228 WP_002210976.1 envelope stress response membrane protein PspB -
M0M60_RS10640 (M0M60_10625) 2346810..2347475 - 666 WP_002210975.1 phage shock protein PspA -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2339806..2340264 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-147)

Antitoxin

(15-147)


Sequences


Toxin        


Download         Length: 153 a.a.        Molecular weight: 16994.38 Da        Isoelectric Point: 4.8732

>T243251 WP_002210981.1 NZ_CP096666:2342831-2343289 [Yersinia pestis EV76-CN]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Download         Length: 459 bp

>T243251 NZ_OW970478:4026014-4026232 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16401.94 Da        Isoelectric Point: 9.7155

>AT243251 WP_002210982.1 NZ_CP096666:2342323-2342769 [Yersinia pestis EV76-CN]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Download         Length: 447 bp

>AT243251 NZ_OW970478:4025613-4025987 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0E8XJV6


Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XFL1

References