Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | /COG5642-COG5654 |
Location | 2342323..2343289 | Replicon | chromosome |
Accession | NZ_CP096666 | ||
Organism | Yersinia pestis EV76-CN |
Toxin (Protein)
Gene name | - | Uniprot ID | A0A0E8XJV6 |
Locus tag | M0M60_RS10610 | Protein ID | WP_002210981.1 |
Coordinates | 2342831..2343289 (+) | Length | 153 a.a. |
Antitoxin (Protein)
Gene name | - | Uniprot ID | Q66A69 |
Locus tag | M0M60_RS10605 | Protein ID | WP_002210982.1 |
Coordinates | 2342323..2342769 (+) | Length | 149 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
M0M60_RS10585 (M0M60_10570) | 2337913..2338887 | - | 975 | WP_002210985.1 | L-Ala-D/L-Glu epimerase | - |
M0M60_RS10590 (M0M60_10575) | 2339050..2339553 | + | 504 | WP_002210984.1 | thiol peroxidase | - |
M0M60_RS10595 (M0M60_10580) | 2339806..2340264 | + | 459 | WP_002213759.1 | IS200/IS605-like element IS1541A family transposase | - |
M0M60_RS10600 (M0M60_10585) | 2340411..2341988 | - | 1578 | WP_002210983.1 | transcriptional regulator TyrR | - |
M0M60_RS10605 (M0M60_10590) | 2342323..2342769 | + | 447 | WP_002210982.1 | DUF2384 domain-containing protein | Antitoxin |
M0M60_RS10610 (M0M60_10595) | 2342831..2343289 | + | 459 | WP_002210981.1 | RES family NAD+ phosphorylase | Toxin |
M0M60_RS10615 (M0M60_10600) | 2343299..2344360 | - | 1062 | WP_002210980.1 | YcjF family protein | - |
M0M60_RS10620 (M0M60_10605) | 2344357..2345754 | - | 1398 | WP_002210979.1 | YcjX family protein | - |
M0M60_RS10625 (M0M60_10610) | 2345735..2345977 | - | 243 | WP_002216375.1 | phage shock protein PspD | - |
M0M60_RS10630 (M0M60_10615) | 2346062..2346421 | - | 360 | WP_002210977.1 | envelope stress response membrane protein PspC | - |
M0M60_RS10635 (M0M60_10620) | 2346421..2346648 | - | 228 | WP_002210976.1 | envelope stress response membrane protein PspB | - |
M0M60_RS10640 (M0M60_10625) | 2346810..2347475 | - | 666 | WP_002210975.1 | phage shock protein PspA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | flank | IS/Tn | - | - | 2339806..2340264 | 458 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 153 a.a. Molecular weight: 16994.38 Da Isoelectric Point: 4.8732
>T243251 WP_002210981.1 NZ_CP096666:2342831-2343289 [Yersinia pestis EV76-CN]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK
Download Length: 459 bp
>T243251 NZ_OW970478:4026014-4026232 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16401.94 Da Isoelectric Point: 9.7155
>AT243251 WP_002210982.1 NZ_CP096666:2342323-2342769 [Yersinia pestis EV76-CN]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT
Download Length: 447 bp
>AT243251 NZ_OW970478:4025613-4025987 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E8XJV6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E8XFL1 |