Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1073720..1074340 Replicon chromosome
Accession NZ_CP096666
Organism Yersinia pestis EV76-CN

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag M0M60_RS04705 Protein ID WP_002208622.1
Coordinates 1073720..1073923 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q66DR4
Locus tag M0M60_RS04710 Protein ID WP_002218472.1
Coordinates 1073972..1074340 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M0M60_RS04675 (M0M60_04675) 1068742..1069080 + 339 WP_002208627.1 P-II family nitrogen regulator -
M0M60_RS04680 (M0M60_04680) 1069120..1070409 + 1290 WP_002228344.1 ammonium transporter AmtB -
M0M60_RS04685 (M0M60_04685) 1070669..1071529 - 861 WP_002208625.1 acyl-CoA thioesterase II -
M0M60_RS04690 (M0M60_04690) 1071786..1072307 + 522 WP_002208624.1 YbaY family lipoprotein -
M0M60_RS04695 (M0M60_04695) 1072443..1072832 - 390 WP_002208623.1 MGMT family protein -
M0M60_RS04705 (M0M60_04705) 1073720..1073923 - 204 WP_002208622.1 expression modulating protein YmoA Toxin
M0M60_RS04710 (M0M60_04710) 1073972..1074340 - 369 WP_002218472.1 Hha toxicity modulator TomB Antitoxin
M0M60_RS04715 (M0M60_04715) 1074499..1074852 - 354 WP_002208619.1 hypothetical protein -
M0M60_RS04720 (M0M60_04720) 1075726..1075869 - 144 WP_002208618.1 type B 50S ribosomal protein L36 -
M0M60_RS04725 (M0M60_04725) 1075885..1076145 - 261 WP_002208617.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T243241 WP_002208622.1 NZ_CP096666:c1073923-1073720 [Yersinia pestis EV76-CN]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T243241 NZ_OW970452:c5214384-5214001 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.00 Da        Isoelectric Point: 4.6121

>AT243241 WP_002218472.1 NZ_CP096666:c1074340-1073972 [Yersinia pestis EV76-CN]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp

>AT243241 NZ_OW970452:c5214626-5214384 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB Q66DR4

References