Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2048475..2049696 Replicon chromosome
Accession NZ_CP096665
Organism Pseudomonas aeruginosa strain PAO1_Mat-X-1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M0419_RS09705 Protein ID WP_003114949.1
Coordinates 2048475..2049053 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag M0419_RS09710 Protein ID WP_003088112.1
Coordinates 2049142..2049696 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M0419_RS09690 (M0419_09690) 2043752..2045029 + 1278 WP_003102743.1 TolC family protein -
M0419_RS09695 (M0419_09695) 2045019..2047190 + 2172 WP_003114950.1 type I secretion system permease/ATPase -
M0419_RS09700 (M0419_09700) 2047180..2048367 + 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
M0419_RS09705 (M0419_09705) 2048475..2049053 - 579 WP_003114949.1 HD domain-containing protein Toxin
M0419_RS09710 (M0419_09710) 2049142..2049696 - 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
M0419_RS09715 (M0419_09715) 2049854..2052049 - 2196 WP_003114948.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
M0419_RS09720 (M0419_09720) 2052054..2052515 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
M0419_RS09725 (M0419_09725) 2052846..2053169 + 324 WP_003102734.1 multidrug efflux SMR transporter -
M0419_RS09730 (M0419_09730) 2053182..2053580 + 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
M0419_RS09735 (M0419_09735) 2053577..2054128 - 552 WP_003102727.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T243237 WP_003114949.1 NZ_CP096665:c2049053-2048475 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

>T243237 NZ_OW970452:4026139-4026357 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT243237 WP_003088112.1 NZ_CP096665:c2049696-2049142 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT243237 NZ_OW970452:4025738-4026112 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References