Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2048248..2049469 Replicon chromosome
Accession NZ_CP096664
Organism Pseudomonas aeruginosa strain PAO1_Kat-X-2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M0418_RS09710 Protein ID WP_003114949.1
Coordinates 2048248..2048826 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag M0418_RS09715 Protein ID WP_003088112.1
Coordinates 2048915..2049469 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M0418_RS09695 (M0418_09695) 2043525..2044802 + 1278 WP_003102743.1 TolC family protein -
M0418_RS09700 (M0418_09700) 2044792..2046963 + 2172 WP_003114950.1 type I secretion system permease/ATPase -
M0418_RS09705 (M0418_09705) 2046953..2048140 + 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
M0418_RS09710 (M0418_09710) 2048248..2048826 - 579 WP_003114949.1 HD domain-containing protein Toxin
M0418_RS09715 (M0418_09715) 2048915..2049469 - 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
M0418_RS09720 (M0418_09720) 2049627..2051822 - 2196 WP_003114948.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
M0418_RS09725 (M0418_09725) 2051827..2052288 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
M0418_RS09730 (M0418_09730) 2052619..2052942 + 324 WP_003102734.1 multidrug efflux SMR transporter -
M0418_RS09735 (M0418_09735) 2052955..2053353 + 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
M0418_RS09740 (M0418_09740) 2053350..2053901 - 552 WP_003102727.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T243230 WP_003114949.1 NZ_CP096664:c2048826-2048248 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

>T243230 NZ_OW970452:330848-331216 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGACAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT243230 WP_003088112.1 NZ_CP096664:c2049469-2048915 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT243230 NZ_OW970452:330630-330851 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References