Detailed information of TA system TA243226

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): virT-relB/YafQ-DinJ
• Location: 74925..75469
• Replicon: chromosome
• Accession: NZ_CP096649
• Organism: Fenollaria massiliensis strain C0061C2

Toxin (Protein)

• Gene name: virT
• Uniprot ID: A0A9E7DJF5
• Locus tag: M1R53_RS00295
• Protein ID: WP_019214516.1
• Coordinates: 75194..75469 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: M1R53_RS00290
• Protein ID: WP_249242655.1
• Coordinates: 74925..75197 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1R53_RS00275 (M1R53_00275)	70138..71508	-	1371	WP_249242652.1	cation:dicarboxylase symporter family transporter	-
M1R53_RS00280 (M1R53_00280)	71789..72778	+	990	WP_249242653.1	PTS sugar transporter subunit IIC	-
M1R53_RS00285 (M1R53_00285)	73118..74596	+	1479	WP_249242654.1	C69 family dipeptidase	-
M1R53_RS00290 (M1R53_00290)	74925..75197	+	273	WP_249242655.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
M1R53_RS00295 (M1R53_00295)	75194..75469	+	276	WP_019214516.1	type II toxin-antitoxin system YafQ family toxin	Toxin
M1R53_RS00300 (M1R53_00300)	75588..76622	-	1035	WP_249242656.1	peptide-methionine (R)-S-oxide reductase MsrB	-
M1R53_RS00305 (M1R53_00305)	76633..77625	-	993	WP_249242657.1	LLM class flavin-dependent oxidoreductase	-
M1R53_RS00310 (M1R53_00310)	77797..78432	+	636	WP_249242659.1	YARHG domain-containing protein	-
M1R53_RS00315 (M1R53_00315)	78984..79181	+	198	WP_249242660.1	DUF4177 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-67)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10529.51 Da
• Isoelectric Point: 10.0313

>T243226 WP_019214516.1 NZ_CP096649:75194-75469 [Fenollaria massiliensis]
MKYKVLLTSKFKKDFKLLKKQGKNTDKILAIINKLAKGEFLDAKYKDHPLLGDYLGARECHIEPDLLLIYEKQENILILN
ILRAGSHSNLF

Nucleotide

• Length: 276 bp

>T243226 NZ_OW970445:58193-58498 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGACGACAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGGCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10215.72 Da
• Isoelectric Point: 4.6702

>AT243226 WP_249242655.1 NZ_CP096649:74925-75197 [Fenollaria massiliensis]
MSNTNLNVRIDKDIKKAAEEVYAELGFNMSTAINMFLRASIRKGGIPFDLKLDVPNKETLEAIEEGRRLAMDPSTPLYDN
MEDLRRALEV

Nucleotide

• Length: 273 bp

>AT243226 NZ_OW970445:57973-58191 [Klebsiella pneumoniae]
ATGAAGCAGCGCATCACTGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA