Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 4132986..4133548 Replicon chromosome
Accession NZ_CP096596
Organism Gordonia amicalis strain 6-1

Toxin (Protein)


Gene name relE Uniprot ID A0A290XKJ4
Locus tag M0655_RS18780 Protein ID WP_006438782.1
Coordinates 4132986..4133276 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7J5WZ76
Locus tag M0655_RS18785 Protein ID WP_006438783.1
Coordinates 4133273..4133548 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M0655_RS18760 (M0655_18760) 4128043..4129675 + 1633 Protein_3705 long-chain fatty acid--CoA ligase -
M0655_RS18765 (M0655_18765) 4130545..4131015 - 471 WP_006438780.1 hypothetical protein -
M0655_RS18770 (M0655_18770) 4131545..4132564 - 1020 WP_191834753.1 IS481 family transposase -
M0655_RS18775 (M0655_18775) 4132657..4132944 - 288 WP_248664701.1 hypothetical protein -
M0655_RS18780 (M0655_18780) 4132986..4133276 - 291 WP_006438782.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M0655_RS18785 (M0655_18785) 4133273..4133548 - 276 WP_006438783.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M0655_RS18790 (M0655_18790) 4133992..4134360 + 369 WP_191834754.1 DUF5313 family protein -
M0655_RS18795 (M0655_18795) 4135491..4136384 + 894 Protein_3712 IS481 family transposase -
M0655_RS18800 (M0655_18800) 4136463..4137188 + 726 WP_191834757.1 peroxiredoxin -
M0655_RS18805 (M0655_18805) 4137264..4137509 - 246 WP_191834758.1 hypothetical protein -
M0655_RS18810 (M0655_18810) 4137718..4138452 - 735 WP_191834759.1 ZIP family metal transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4131545..4147627 16082


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(14-94)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10789.30 Da        Isoelectric Point: 11.1310

>T243225 WP_006438782.1 NZ_CP096596:c4133276-4132986 [Gordonia amicalis]
MSDAPTDSPAPYRVEVASPARRDLQRLPSRIVHAVIEFISGPLAGNPHRLSKPLRNDLAGLHSARRGDYRVLLRIDDPNH
TIVVVRIDHRAHAYRT

Download         Length: 291 bp

>T243225 NZ_OW970444:c5322435-5322052 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9740.91 Da        Isoelectric Point: 4.6221

>AT243225 WP_006438783.1 NZ_CP096596:c4133548-4133273 [Gordonia amicalis]
MTTVPLGEAKDKLSALVDSAETTHDIITITKHGKPAAVLMSADDLESLHETIYWLSRAGVRDDVATADAEYAAGHTVSID
DLRAEHGMPPK

Download         Length: 276 bp

>AT243225 NZ_OW970444:c5322677-5322435 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A290XKJ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7J5WZ76

References