Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 589797..590458 Replicon chromosome
Accession NZ_CP096593
Organism Paracoccus denitrificans strain DYTN-1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M0K93_RS03200 Protein ID WP_011746828.1
Coordinates 590057..590458 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A5P8JJZ9
Locus tag M0K93_RS03195 Protein ID WP_011746827.1
Coordinates 589797..590060 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M0K93_RS03170 (M0K93_03175) 585635..586801 + 1167 WP_011746823.1 alpha/beta hydrolase -
M0K93_RS03175 (M0K93_03180) 586798..587571 + 774 WP_011746824.1 SDR family oxidoreductase -
M0K93_RS03180 (M0K93_03185) 587707..588945 + 1239 WP_011746825.1 MFS transporter -
M0K93_RS03185 (M0K93_03190) 589140..589289 - 150 Protein_625 IS5/IS1182 family transposase -
M0K93_RS03190 (M0K93_03195) 589413..589559 - 147 Protein_626 IS3 family transposase -
M0K93_RS03195 (M0K93_03200) 589797..590060 + 264 WP_011746827.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
M0K93_RS03200 (M0K93_03205) 590057..590458 + 402 WP_011746828.1 type II toxin-antitoxin system VapC family toxin Toxin
M0K93_RS03205 (M0K93_03210) 591298..591624 + 327 WP_241663482.1 type II toxin-antitoxin system RelE/ParE family toxin -
M0K93_RS03210 (M0K93_03215) 591621..591899 + 279 WP_041529754.1 helix-turn-helix domain-containing protein -
M0K93_RS03215 (M0K93_03220) 592009..592392 + 384 WP_011746831.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(16-53)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14135.25 Da        Isoelectric Point: 5.1700

>T243220 WP_011746828.1 NZ_CP096593:590057-590458 [Paracoccus denitrificans]
MTLYMLDTNIVSDLLRHPDGSAAKRIAEVGPDAICVSIITAAELRYGCARKGSAKLLAHVEAILENVQVLALDVPADAEY
GGIRAELEAAGKPIGPNDLLIAAHAYAAGAILVTDNTGEFSRVRGLRVENWIR

Download         Length: 402 bp

>T243220 NZ_OW970444:c2765729-2764407 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGAGGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTTTCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCGCCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCTACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9842.23 Da        Isoelectric Point: 4.8232

>AT243220 WP_011746827.1 NZ_CP096593:589797-590060 [Paracoccus denitrificans]
MPHPQPSSGPREAKLFRNNKSQAVRIPADFEMPGDRVNIYRDGNRLIIEPLRRKNLLEVLAGLDPLGPEDQFPDVDETLL
PAKEIDL

Download         Length: 264 bp

>AT243220 NZ_OW970444:c2765995-2765729 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGATGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5P8JJZ9

References