Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | spoIISABC/SpoIISA-SpoIISB |
| Location | 1370743..1371659 | Replicon | chromosome |
| Accession | NZ_CP096590 | ||
| Organism | Bacillus rugosus strain A78.1 | ||
Toxin (Protein)
| Gene name | spoIISA | Uniprot ID | - |
| Locus tag | M0696_RS07025 | Protein ID | WP_248602643.1 |
| Coordinates | 1370913..1371659 (-) | Length | 249 a.a. |
Antitoxin (Protein)
| Gene name | spoIISB | Uniprot ID | G4NV07 |
| Locus tag | M0696_RS07020 | Protein ID | WP_003239095.1 |
| Coordinates | 1370743..1370913 (-) | Length | 57 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M0696_RS06985 (1367619) | 1367619..1367948 | + | 330 | WP_248602639.1 | XkdW family protein | - |
| M0696_RS06990 (1367945) | 1367945..1368109 | + | 165 | WP_248602640.1 | XkdX family protein | - |
| M0696_RS06995 (1368155) | 1368155..1368988 | + | 834 | WP_248602641.1 | phage portal protein | - |
| M0696_RS07000 (1369041) | 1369041..1369310 | + | 270 | WP_014113495.1 | hemolysin XhlA family protein | - |
| M0696_RS07005 (1369323) | 1369323..1369586 | + | 264 | WP_166853520.1 | phage holin | - |
| M0696_RS07010 (1369599) | 1369599..1370492 | + | 894 | WP_166853519.1 | N-acetylmuramoyl-L-alanine amidase | - |
| M0696_RS07015 (1370520) | 1370520..1370657 | - | 138 | WP_248602642.1 | three component toxin-antitoxin-antitoxin system antitoxin SpoIISC | - |
| M0696_RS07020 (1370743) | 1370743..1370913 | - | 171 | WP_003239095.1 | three component toxin-antitoxin-antitoxin system antitoxin SpoIISB | Antitoxin |
| M0696_RS07025 (1370913) | 1370913..1371659 | - | 747 | WP_248602643.1 | toxin-antitoxin-antitoxin system toxin SpoIISA | Toxin |
| M0696_RS07030 (1371769) | 1371769..1372770 | - | 1002 | WP_166853516.1 | inorganic phosphate transporter | - |
| M0696_RS07035 (1372783) | 1372783..1373400 | - | 618 | WP_003218470.1 | DUF47 domain-containing protein | - |
| M0696_RS07040 (1373677) | 1373677..1374993 | - | 1317 | WP_248602644.1 | serine/threonine exchanger | - |
| M0696_RS07045 (1375379) | 1375379..1376329 | + | 951 | WP_222142669.1 | ring-cleaving dioxygenase | - |
| M0696_RS07050 (1376411) | 1376411..1376575 | + | 165 | WP_248602645.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 249 a.a. Molecular weight: 29043.50 Da Isoelectric Point: 4.6191
>T243211 WP_248602643.1 NZ_CP096590:c1371659-1370913 [Bacillus rugosus]
MLLFFQIMVWCIMAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMIYWTYDSSSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIEAYAEGIDKLLKTYADKMSLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQSYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG
MLLFFQIMVWCIMAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMIYWTYDSSSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIEAYAEGIDKLLKTYADKMSLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQSYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG
Download Length: 747 bp
>T243211 NZ_OW970436:c4667416-4666883 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
Antitoxin
Download Length: 57 a.a. Molecular weight: 6555.59 Da Isoelectric Point: 10.8401
>AT243211 WP_003239095.1 NZ_CP096590:c1370913-1370743 [Bacillus rugosus]
MERAFQNGCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA
MERAFQNGCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA
Download Length: 171 bp
>AT243211 NZ_OW970436:c4667693-4667427 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|