Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
| Location | 521547..522183 | Replicon | chromosome |
| Accession | NZ_CP096590 | ||
| Organism | Bacillus rugosus strain A78.1 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | G4NU33 |
| Locus tag | M0696_RS02645 | Protein ID | WP_003156187.1 |
| Coordinates | 521833..522183 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | G4NU32 |
| Locus tag | M0696_RS02640 | Protein ID | WP_003225183.1 |
| Coordinates | 521547..521828 (+) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M0696_RS02620 (517906) | 517906..518505 | - | 600 | WP_166854227.1 | rhomboid family intramembrane serine protease | - |
| M0696_RS02625 (518600) | 518600..518965 | + | 366 | WP_166854226.1 | holo-ACP synthase | - |
| M0696_RS02630 (519130) | 519130..520146 | + | 1017 | WP_166854225.1 | outer membrane lipoprotein carrier protein LolA | - |
| M0696_RS02635 (520261) | 520261..521430 | + | 1170 | WP_222143581.1 | alanine racemase | - |
| M0696_RS02640 (521547) | 521547..521828 | + | 282 | WP_003225183.1 | type II toxin-antitoxin system antitoxin EndoAI | Antitoxin |
| M0696_RS02645 (521833) | 521833..522183 | + | 351 | WP_003156187.1 | type II toxin-antitoxin system endoribonuclease NdoA | Toxin |
| M0696_RS02650 (522300) | 522300..523124 | + | 825 | WP_166854223.1 | RsbT co-antagonist protein RsbRA | - |
| M0696_RS02655 (523129) | 523129..523494 | + | 366 | WP_003225190.1 | RsbT antagonist protein RsbS | - |
| M0696_RS02660 (523498) | 523498..523899 | + | 402 | WP_014112733.1 | serine/threonine-protein kinase RsbT | - |
| M0696_RS02665 (523911) | 523911..524918 | + | 1008 | WP_248602455.1 | phosphoserine phosphatase RsbU | - |
| M0696_RS02670 (524981) | 524981..525310 | + | 330 | WP_014662855.1 | anti-sigma factor antagonist RsbV | - |
| M0696_RS02675 (525307) | 525307..525789 | + | 483 | WP_003225198.1 | anti-sigma B factor RsbW | - |
| M0696_RS02680 (525755) | 525755..526543 | + | 789 | WP_003225200.1 | RNA polymerase sigma factor SigB | - |
| M0696_RS02685 (526543) | 526543..527142 | + | 600 | WP_166854220.1 | phosphoserine phosphatase RsbX | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12977.98 Da Isoelectric Point: 4.8781
>T243210 WP_003156187.1 NZ_CP096590:521833-522183 [Bacillus rugosus]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
Download Length: 351 bp
>T243210 NZ_OW970436:4039460-4039678 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10546.92 Da Isoelectric Point: 6.4708
>AT243210 WP_003225183.1 NZ_CP096590:521547-521828 [Bacillus rugosus]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAEC
EAETTVERLVSGG
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAEC
EAETTVERLVSGG
Download Length: 282 bp
>AT243210 NZ_OW970436:4039059-4039433 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|