Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 4921109..4922064 Replicon chromosome
Accession NZ_CP096585
Organism Gordonia terrae strain PE42

Toxin (Protein)


Gene name pezT Uniprot ID -
Locus tag M1C59_RS22080 Protein ID WP_101819598.1
Coordinates 4921109..4921684 (-) Length 192 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag M1C59_RS22085 Protein ID WP_248643741.1
Coordinates 4921681..4922064 (-) Length 128 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1C59_RS22050 (M1C59_22050) 4916571..4917578 + 1008 WP_248643736.1 LacI family DNA-binding transcriptional regulator -
M1C59_RS22055 (M1C59_22055) 4917601..4918281 - 681 WP_248643737.1 hypothetical protein -
M1C59_RS22060 (M1C59_22060) 4918380..4918694 - 315 WP_248643738.1 DUF2470 domain-containing protein -
M1C59_RS22065 (M1C59_22065) 4918687..4919418 - 732 WP_248643739.1 tyrosine-protein phosphatase -
M1C59_RS22070 (M1C59_22070) 4919511..4920143 + 633 WP_101819600.1 flavin reductase family protein -
M1C59_RS22075 (M1C59_22075) 4920165..4921112 - 948 WP_248643740.1 PfkB family carbohydrate kinase -
M1C59_RS22080 (M1C59_22080) 4921109..4921684 - 576 WP_101819598.1 zeta toxin family protein Toxin
M1C59_RS22085 (M1C59_22085) 4921681..4922064 - 384 WP_248643741.1 ParD-like family protein Antitoxin
M1C59_RS22090 (M1C59_22090) 4922188..4922736 - 549 WP_248643742.1 peptide-methionine (S)-S-oxide reductase MsrA -
M1C59_RS22095 (M1C59_22095) 4922733..4923215 - 483 WP_248643743.1 peptide-methionine (R)-S-oxide reductase MsrB -
M1C59_RS22100 (M1C59_22100) 4923375..4924598 - 1224 WP_248645663.1 acyl-CoA dehydrogenase family protein -
M1C59_RS22105 (M1C59_22105) 4924677..4925759 - 1083 WP_101819859.1 VOC family protein -
M1C59_RS22110 (M1C59_22110) 4926007..4926900 + 894 WP_248643744.1 acetaldehyde dehydrogenase (acetylating) -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(2-142)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(7-66)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21061.01 Da        Isoelectric Point: 8.1649

>T243180 WP_101819598.1 NZ_CP096585:c4921684-4921109 [Gordonia terrae]
VTPRLDLVVGCNGAGKSTLVEHHLQPLVRTPFVNADLIARQQWPDAAEAHSYDAARLAAATRDHLIEAGASFIAETVFSH
PSKLELVDRAHTAGYRVALHVVMIPEDLAVHRVRLRVDSGGHAVPEVKIRERFRRLWPLVRTAILRSDQATVYANERATT
RIVARYVDGMVAGVPDWPDWTPGALTGSEAR

Download         Length: 576 bp

>T243180 NZ_CP096585:c4921684-4921109 [Gordonia terrae]
GTGACACCGAGGCTCGACCTCGTCGTCGGATGCAACGGCGCGGGAAAGTCGACGCTGGTCGAGCATCATCTACAGCCGTT
GGTGCGCACACCCTTCGTGAACGCCGACCTGATCGCCCGGCAGCAGTGGCCCGACGCCGCGGAAGCCCACTCCTACGACG
CGGCCCGGTTGGCCGCGGCCACCCGCGACCACCTCATCGAGGCCGGTGCCTCGTTCATCGCCGAGACGGTCTTCTCGCAT
CCGTCGAAACTGGAACTCGTCGACCGTGCGCACACCGCCGGATACCGGGTCGCTCTCCACGTCGTGATGATCCCCGAAGA
TCTCGCCGTGCATCGGGTGCGGCTACGCGTCGACAGTGGCGGGCATGCGGTCCCGGAGGTCAAGATCCGCGAGCGGTTCC
GACGCCTGTGGCCGCTCGTCCGCACGGCGATCCTGCGGAGTGACCAGGCAACCGTGTACGCCAACGAGCGAGCGACCACG
CGCATCGTCGCGCGGTACGTCGACGGTATGGTCGCGGGCGTGCCCGACTGGCCCGACTGGACGCCGGGGGCGCTCACGGG
TTCGGAGGCACGATGA

Antitoxin


Download         Length: 128 a.a.        Molecular weight: 13765.23 Da        Isoelectric Point: 5.2682

>AT243180 WP_248643741.1 NZ_CP096585:c4922064-4921681 [Gordonia terrae]
MSTGTDKVTRLSAALVTDAAREGAREQRSARQQLEHWARLGRSVSQRTTASRRRVEAALAGDLPAEALTAEEAVVYDAEI
DAHLEARLATDDHVVRRASEGFSSVVVDDAGRLVELRPDGTSVVLDR

Download         Length: 384 bp

>AT243180 NZ_CP096585:c4922064-4921681 [Gordonia terrae]
ATGAGCACCGGTACGGACAAGGTGACCCGGTTGTCTGCTGCACTGGTGACCGATGCCGCGCGGGAGGGCGCGCGCGAGCA
GCGATCGGCGCGGCAGCAACTCGAACACTGGGCACGTCTCGGCCGCAGCGTCTCACAGCGCACCACCGCGTCGCGTCGGC
GGGTCGAGGCCGCGTTGGCCGGCGACCTACCGGCAGAGGCGTTGACCGCAGAGGAAGCCGTCGTCTACGACGCCGAGATC
GACGCGCACCTCGAGGCGCGGCTGGCCACCGACGACCACGTCGTCCGACGCGCCTCGGAGGGGTTCTCCTCGGTCGTCGT
CGATGACGCCGGACGGCTCGTCGAACTCCGGCCCGACGGGACGAGCGTCGTCCTCGACCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References